Clinical studyA randomized trial of dexamethasone and acetazolamide for acute mountain sickness prophylaxis
References (33)
- et al.
Cerebral form of high altitude illness
Lancet
(1975) - et al.
Phenytoin and acute mountain sickness on Mount Everest
Am J Med
(1986) - et al.
Acute mountain sickness
N Engl J Med
(1969) - et al.
The incidence, importance, and prophylaxis of acute mountain sickness
Lancet
(1976) High altitude illness: disease with protean manifestations
JAMA
(1976)High altitude medical problems
West J Med
(1979)- et al.
Mountaineering accidents in the Sierra Nevada
Am J Sports Med
(1983) - et al.
Evaluation of an acute mountain sickness questionnaire: effects of intermediate-altitude staging upon subjective symptomatology
Avait Space Environ Med
(1980) - et al.
Acute mountain sickness and acetazolamide: clinical efficacy and effect on ventilation
JAMA
(1982) Acetazolamide in the control of acute mountain sickness
Lancet
(1981)
Amelioration of the symptoms of acute mountain sickness by staging and acetazolamide
Avait Space Environ Med
Control of acute mountain sickness
Aerospace Med
Effect of acetazolamide on acute mountain sickness
N Engl J Med
Low doses of acetazolamide to aid accommodation of men to altitude
J Appl Physiol
Prevention of acute mountain sickness by dexamethasone
N Engl J Med
Dexamethasone in the treatment of acute mountain sickness
N Engl J Med
Cited by (105)
Wilderness Medical Society Clinical Practice Guidelines for the Prevention, Diagnosis, and Treatment of Acute Altitude Illness: 2024 Update
2023, Wilderness and Environmental MedicineHigh-altitude illnesses: Old stories and new insights into the pathophysiology, treatment and prevention
2021, Sports Medicine and Health ScienceCitation Excerpt :Finally, non-steroidal anti-inflammatory drugs like ibuprofen may represent an alternative or an add on to acetazolamide for AMS prevention.138 Dexamethasone is an efficient drug in preventing severe AMS, HACE, and HAPE.8,11,104,125,139 With regard to HACE, concerns have been raised whether dexamethasone treatment of severe and life-threatening HACE is still effective with preexisting dexamethasone prophylaxis and therefore represents a second-line strategy.
Efficacy of Acetazolamide for the Prophylaxis of Acute Mountain Sickness: A Systematic Review, Meta-Analysis and Trial Sequential Analysis of Randomized Clinical Trials
2021, American Journal of the Medical SciencesCitation Excerpt :The PRISMA flow diagram of literature search was shown in Figure 1. The 22 selected trials comprised of 2019 participants with 1094 subjects receiving acetazolamide and 925 taking placebo.11,12,20-39 The proportions of males ranged from 49% to 100%, and the mean age ranged from 20.3 to 43.6 years.
A Randomized Controlled Trial of the Lowest Effective Dose of Acetazolamide for Acute Mountain Sickness Prevention
2020, American Journal of MedicineAcute high-altitude pathologies and their treatment
2020, Current Opinion in Endocrine and Metabolic ResearchWilderness Medical Society Clinical Practice Guidelines for the Prevention and Treatment of Acute Altitude Illness: 2019 Update
2019, Wilderness and Environmental MedicineCitation Excerpt :Recommendation Grade: 1C. Although dexamethasone does not facilitate acclimatization like acetazolamide, prospective trials have established a benefit for dexamethasone in AMS prevention.28,29 The recommended adult doses are 2 mg every 6 h or 4 mg every 12 h. Very high doses (4 mg every 6 h) may be considered in very high-risk situations, such as military or search and rescue personnel being airlifted to altitudes >3500 m with immediate performance of physical activity, but should not be used except in these limited circumstances.