Elsevier

Analytical Biochemistry

Volume 136, Issue 1, January 1984, Pages 202-207
Analytical Biochemistry

Regular article
Gas-liquid chromatographic determination of total phenylacetic acid in urine

https://doi.org/10.1016/0003-2697(84)90326-9Get rights and content

Abstract

A gas-liquid chromatographic procedure to measure total phenylacetic acid in urine is described. The method is simple, rapid, and reliable. Normal subjects (N = 48) excreted 141.1 ± 10.1 mg/24 h. Untreated depressed patients (N = 42) excreted 102.77 ± 15.9 mg/24 h. The difference in the means is significant and supports the role of phenylacetic acid as a biological marker in certain kinds of mental illnesses.

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