PDGF-BB, IGF-I and mechanical load stimulate DNA synthesis in avian tendon fibroblasts in vitro
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2022, Chemico-Biological InteractionsCitation Excerpt :Furthermore, the b-FGF, IGF, and their variants play an essential part in tissue repair & regeneration by increasing cellular proliferation, protein production, collagen formation, and other biological responses [52–55]. Many researchers have been intrigued by the anabolic properties of IGF [56]. There are several growth factors in wound healing and scar formation, one of which is TGF-b. Cells that generate TGF-b during wound healing include smooth muscle cells, epithelium and fibroblasts as well as lymphocytes and endothelial cells [57].
Microscopic characterisation of local strain field in healing tissue in the central third defect of mouse patellar tendon at early-phase of healing
2021, Journal of the Mechanical Behavior of Biomedical MaterialsCitation Excerpt :These findings may highlight the importance of mechanical stimulation to healing tissue cells by shear deformation for better tissue repair. It should be noted that cells in paratenon and epitenon are possibly less mechanoresponsive than internal tenocytes (Banes et al., 1995), and therefore an application of a higher level of mechanical stimulation and/or the implantation of a scaffold material into the defect site to induce the alignment of the infiltrating cells to tendon loading axis may be required to promote tissue healing. It was one of the limitations in the present study that we analysed the microscopic strain at only one deformation point (4% microscopic tissue strain level); this was because the microscopic tissue strain in the control tendon was markedly smaller than that in H3w and H6w at each 100-μm macroscopic stretch step (Fig. 5(a)).
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