ArticleAdapting to phase shifts, II. Effects of melatonin and conflicting light treatment
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2018, Sleep HealthCitation Excerpt :This is consistent with our finding that a majority of the participants who collected urine samples experienced a circadian phase shift to an earlier hour relative to baseline. Although we found that early starts were associated with short sleep duration and poorer performance, circadian adaptation to early starts is possible with precise control of light and darkness.25 The circadian phase shifting response to light follows a phase response curve (PRC), such that light timed in the relative morning (after the circadian nadir) leads to an advance phase shift and light timed in the relative evening (before the circadian nadir) leads to a delay phase shift.26,27
Managing jet lag: Some of the problems and possible new solutions
2009, Sleep Medicine ReviewsCitation Excerpt :If biological night-time is known, correct timing of light or chronobiotics to induce a particular shift can be predicted. One of the more interesting features of the use of melatonin is that it apparently influences the direction of shift when pre-flight treatment is employed,65 and can at least partially counter the effects of conflicting bright light exposure.78 Whether to aid adaptation or not depends on the length of time to be spent in the destination time zone.
Physiology and pharmacology of melatonin in relation to biological rhythms
2009, Pharmacological ReportsCitation Excerpt :Pre-flight treatment with melatonin can be timed to initiate a shift in the right direction (but has rarely been used) [16, 256, 271]. In field studies, individual variability is large and exposure to conflicting natural bright light is always a problem, although one simulation study has shown that melatonin can partially counter conflicting light [70]. The American Academy of Sleep Medicine has recently published a positive recommendation for the use of melatonin in jet lag, non-24 h sleep-wake disorder, and some other circadian rhythm sleep-wake disorders [221].
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