Brief communicationInfluences of strenuous exercise (triathlon) on blood coagulation and fibrinolytic system
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2021, Apunts Sports MedicineBlood Hemostatic Changes During an Ultraendurance Road Cycling Event in a Hot Environment
2017, Wilderness and Environmental MedicineCitation Excerpt :Moreover, with the rising popularity of ultraendurance running and cycling over the last decade1 it has become imperative to better understand the effects of these events on human physiology. Ultraendurance events (running, cycling, and triathlon) have been shown to induce changes in blood homeostasis, including platelet activation, coagulation, and fibrinolysis.2–5 We followed subjects in the Hotter ’N Hell Hundred (HHH), which typically generates great physiological stress, seen by cyclists losing 2% of their body mass despite intaking fluids approaching 1 L/h,6 as it consists of a 164-km bicycle ride in northern Texas during summer heat that annually exceeds 37°C.
The impact of exercise-induced core body temperature elevations on coagulation responses
2017, Journal of Science and Medicine in SportCitation Excerpt :The increased thrombin enables fibrin formation, which stabilizes the platelet plug.4 Simultaneous to these prothrombotic changes, increased levels of tissue plasminogen activator and reduced levels of plasminogen activator inhibitor hallmark increased fibrinolysis.1,3,4 In this manner, the prothrombotic effects of exercise are offset by increased fibrinolysis, which prevents the formation of excess blood clots.
Short- and Long-term exercise induced alterations in haemostasis: A review of the literature
2015, Blood ReviewsCitation Excerpt :An indirect marker of fibrin formation, but also of its cleavage, is the d-dimer level, or in former assays fibrin degradation products (FDP's). Mandalaki et al. found increased levels after long-term exercise and most other manuscripts supported this, independent of duration and intensity [6,8,24,26,39,44,65,69,73,75,77,79,81,88–90]. Speiser et al. found no changes in d-dimer levels after short-term exercise and 2 other studies describing d-dimer levels in order to short- and long-term exercise supported this [39,78,91].