Postgraduate course presentation
Physical urticaria/angioedema: An experimental model of mast cell activation in humans

https://doi.org/10.1016/0091-6749(80)90114-1Get rights and content

Abstract

Urticaria and angioedema may occur in skin and mucus membranes when mast cells are activated by various physical stimuli, including trauma, pressure, vibration, light, cold, heat, and (in rare cases) water. Experimental challenge of patients with cold-induced and cholinergic urticaria/angioedema in particular provides an in vivo model of mast cell activation in humans. This model synthesizes observations of the evolution of clinical manifestations, histologic analysis of tissue alterations, measurement of mediators released into the circulation, and assessment of leukocyte motility. The model in turn allows a characterization of mediators that exist preformed in mast cell granules or that are generated through interactions with other cell types. Release of these mediators produces a variety of biologic effects, including elaboration of certain enzymes and alterations in venular permeability, smooth muscle contraction, leukocyte motility, and the release of substances from other cell types.

References (94)

  • L Daman et al.

    Localized heat urticaria

    J Allergy Clin Immunol

    (1978)
  • GR Mikhail et al.

    Mast cell population in human skin

    J Invest Dermatol

    (1964)
  • JT Crissey et al.

    Cutaneous thermography with liquid crystals

    J Invest Dermatol

    (1965)
  • MK Bach et al.

    On the structure of slow reacting substance of anaphylaxis: Evidence of biosynthesis from arachidonic acid

    Prostaglandins

    (1977)
  • RP Orange et al.

    Slow reacting substance of anaphylaxis

    Adv Immunol

    (1969)
  • CA Demopoulos et al.

    Platelet activating factor: Evidence for 1-o-alkyl-2-acetyl-sn-glyceryl-3-phosphoylcholine as the active component (a new class of lipid chemical mediators)

    J Biol Chem

    (1979)
  • LM Solomon et al.

    Prostaglandin on cutaneous vasculature

    J Invest Dermatol

    (1968)
  • D Lagunoff et al.

    N-Acetyl-β-glucosaminidase in rat mast cell granules

    Exp Cell Res

    (1970)
  • LB Schwartz et al.

    Enzymes of the mast cell granule

    J Invest Dermatol

    (1980)
  • SI Wasserman et al.

    Identification and characterization of arylsulfatase A and B of the rat basophil leukemia tumor

    J Biol Chem

    (1977)
  • RW Yurt et al.

    Native heparin from rat peritoneal mast cells

    J Biol Chem

    (1977)
  • DD Metcalfe et al.

    Identification of sulfated mucopolysaccharides including heparin in the lesional skin of a patient with mastocytosis

    J Invest Dermatol

    (1980)
  • CB Bentley-Phillips et al.

    Induced cold tolerance in cold urticaria caused by cold-evoked histamine release

    Lancet

    (1976)
  • RK Ebken et al.

    Dermographism: Its definition, demonstration, and prevention

    J Allergy

    (1968)
  • JD Kirby et al.

    The incidence and other aspects of factitious wealing (dermographism)

    Br J Dermatol

    (1971)
  • N Launa et al.

    The fine morphology of the human skin in dermographism

    J Allergy

    (1970)
  • S Kalz et al.

    Delayed and persistent dermographia

    Arch Dermatol Syphil

    (1950)
  • RD Baughman et al.

    Seven specific types of urticaria: With special reference to delayed persistent dermographism

    Ann Allergy

    (1963)
  • TJ Ryan et al.

    Delayed pressure urticaria

    Br J Dermatol

    (1968)
  • JJ Costanzi et al.

    Activation of complement by a monoclonal cryoglobulin associated with cold urticaria

    J Lab Clin Med

    (1969)
  • NA Soter et al.

    Cold urticaria: Release into the circulation of histamine and eosinophil chemotactic factor of anaphylaxis during cold challenge

    N Engl J Med

    (1976)
  • SI Wasserman et al.

    Cold urticaria: Recognition and characterization of a neutrophil chemotactic factor which appears in serum during experimental cold challenge

    J Clin Invest

    (1977)
  • DM Center et al.

    In vivo deactivation of human neutrophils to a subsequent in vitro chemotactic stimulus

    Clin Res

    (1977)
  • JP Tindall et al.

    Familial cold urticaria: A generalized reaction involving leukocytosis

    Arch Intern Med

    (1969)
  • H Ive et al.

    Action spectra in idiopathic solar urticaria. A study of 17 cases with a monochromator

    Br J Dermatol

    (1965)
  • JLM Hawk et al.

    Elevated blood histamine levels mast cell degranulation in solar urticaria

    Br J Clin Pharmacol

    (1980)
  • NA Soter et al.

    Solar urticaria: Release of mast mediators into the circulation after experimental challenge

    J Invest Dermatol

    (1979)
  • T Horio

    Photoallergic urticaria induced by visible light: Additional cases and further studies

    Arch Dermatol

    (1978)
  • NA Soter et al.

    Mast cell mediator release and alteration in lung function in individuals with cholinergic urticaria

    N Engl J Med

    (1980)
  • CA Commens et al.

    Tests to establish the diagnosis in cholinergic urticaria

    Br J Dermatol

    (1978)
  • WB Shelley et al.

    Aquagenic urticaria: Contact sensitivity reaction to water

    JAMA

    (1964)
  • TA Tromovitch

    Urticaria from contact with water

    California Med

    (1967)
  • DM Center et al.

    Inhibition of neutrophil chemotaxis in association with experimental angioedema in patients with cold urticaria: A model of chemotactic deactivation in vivo

    Clin Exp Immunol

    (1979)
  • SI Wasserman et al.

    Eosinophil chemotactic factors in human disease: Evidence of heterogeneity

    Clin Res

    (1980)
  • PGH Gell et al.

    The classification of allergic reactions underlying disease

  • NA Soter et al.

    Cutaneous necrotizing venulitis: A sequential analysis of the morphological alterations occurring after mast cell degranulation in a patient with a unique syndrome

    Clin Exp Immunol

    (1978)
  • CM Trotter et al.

    A fine structure study of some cellular components in allergic reactions. II. Mast cells in normal and atopic human skin

    Clin Allergy

    (1974)
  • Cited by (0)

    Presented at the Postgraduate Course in Allergy and Clinical Immunology at the meeting of the American Academy of Allergy in Atlanta, Ga., February, 1980.

    Recipient of a Young Investigator Research Grant (AI-14292) from the National Institutes of Health.

    View full text