COMMENTARYDRUG REACTIONS: Sumatriptan and chest pain
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Cited by (46)
5-Hydroxytryptamine receptors in the human cardiovascular system
2006, Pharmacology and TherapeuticsCitation Excerpt :Tightness of chest is observed in 3–5% of patients treated with sumatriptan (Brown et al., 1991; Tansey et al., 1993), the triptan mostly used in migraine. Tightness of chest could be due to a variety of causes, including coronary vasospasm, pulmonary vasoconstriction and/or activation of sensory nerve endings (Hillis & MacIntyre, 1993). On occasion, sumatriptan can produce anginal chest pain and ischaemia (Willett et al., 1992), associated with ventricular fibrillation (Curtin et al., 1992) and transmural infarction (Ottervanger et al., 1993, 1997), possibly due to coronary artery constriction via 5-HT1B receptors.
Imidazoline-modified benzylimidazolines as h5-HT<inf>1D/1B</inf> serotonergic ligands
2001, Bioorganic and Medicinal ChemistryRizatriptan in the treatment of migraine
1999, Clinical TherapeuticsEffects of ergotamine on myocardial blood flow in migraineurs without evidence of atherosclerotic coronary artery disease
1998, American Journal of CardiologySumatriptan therapy for headache and acute myocardial infarction
2010, Expert Opinion on Pharmacotherapy
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