Elsevier

The Lancet

Volume 341, Issue 8860, 19 June 1993, Pages 1564-1565
The Lancet

COMMENTARY
DRUG REACTIONS: Sumatriptan and chest pain

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    Tightness of chest is observed in 3–5% of patients treated with sumatriptan (Brown et al., 1991; Tansey et al., 1993), the triptan mostly used in migraine. Tightness of chest could be due to a variety of causes, including coronary vasospasm, pulmonary vasoconstriction and/or activation of sensory nerve endings (Hillis & MacIntyre, 1993). On occasion, sumatriptan can produce anginal chest pain and ischaemia (Willett et al., 1992), associated with ventricular fibrillation (Curtin et al., 1992) and transmural infarction (Ottervanger et al., 1993, 1997), possibly due to coronary artery constriction via 5-HT1B receptors.

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