The effect of β-agonists and antagonists on muscle growth and body composition of young rats (Rattus sp.)
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Win 55,212-2, atenolol and subdiaphragmatic vagotomy prevent acceleration of gastric emptying induced by cachexia via Yoshida-AH-130 cells in rats
2020, European Journal of PharmacologyCitation Excerpt :We suggest that this may be related to changes in body composition due to atenolol treatment. According to Reeds et al. (1988), atenolol co-treatment (20 mg/kg) caused a significant decrease in cardiac muscle RNA and protein levels in rats treated with clenbuterol (2 mg/kg), an adrenergic agonist. Studies of the sympathetic regulation of tumor development in cachectic animals has shown that pharmacological sympathectomy with 6-hydroxydopamine hydrobromide did not affect the incidence of ascitic tumor causing cachexia (Horvathova et al., 2015).
Beta-2 agonists and exercise performance in humans
2010, Science and SportsCitation Excerpt :Martineau et al. [15] found that salbutamol (16 mg/day for 3 weeks) did not affect lean body mass in healthy males. Caruso et al. [14] examined the effect of 16 mg/day of salbutamol for 6 weeks during a 9-week resistance training program in healthy males and also found that the drug did not modify muscle mass. In another study, the same authors [17] obtained approximately the same results with 16 mg/day of salbutamol for 2 weeks after 10 weeks of resistance training, with, however, a trend toward higher lean body mass with salbutamol.
Clenbuterol and the horse revisited
2009, Veterinary JournalSteroid and β-adrenergic receptor modifications in target organs of broiler chickens fed with a diet containing β<inf>2</inf>-adrenergic agents
2008, Food and Chemical ToxicologyCitation Excerpt :The possible direct activation of β-ARs on skeletal muscle and adipocyte could be a potential explanation for the repartitioning effects elicited by β-agonists. Even though initially it seemed that the anabolic effect of β2-agonists in rats was not blocked by antagonist such as propranolol (Maltin et al., 1987; Reeds et al., 1988), further research confirmed that clenbuterol and similar compounds exerted their anabolic effect via β2-AR activation (Maclennan and Edwards, 1989; Sillence et al., 1991; Choo et al., 1992). The effect of β2-agonists are highly selective for skeletal muscle and they mobilize protein from other tissues, such as the gut (Sillence, 2004).
Technologies for the control of fat and lean deposition in livestock
2004, Veterinary Journal
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