CardiomyopathyIsolated Left Ventricular Noncompaction Syndrome
Section snippets
Methods
Patients were identified by searching the master diagnosis list and echocardiographic databases at the Mayo Clinic (Rochester, Minnesota) using the keywords “noncompaction” and “noncompaction” and the date range 2001 to 2006. Pediatric patients (age <16 years) and patients with other concomitant congenital heart disease were excluded. A comprehensive chart review was conducted to evaluate clinical data that were systematically entered into a database for analysis. Clinical data abstracted
Results
The initial database search identified 130 patients; 72 were excluded (46 had coexisting congenital disorders, 21 were <16 years old, 4 refused participation, and 1 had insufficient clinical information). Nineteen additional patients were excluded because index echocardiograms were unavailable for review. Echocardiographic data were reviewed in the remaining 39 patients. After study review of the images, 9 patients with echocardiographic reports listing ILVNC among the final diagnosis did not
Discussion
Awareness of ILVNC has increased substantially in recent years and it has been recognized as an “unclassified” cardiomyopathy by the World Health Organization.15 Interest has focused mainly on the concern that incompletely formed endocardium with channels and trabeculae may provide substrate for thromboembolic events, and that these patients might be at risk for the development of malignant ventricular tachyarrhythmias and LV systolic dysfunction. ILVNC has been the subject of several small,
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