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Physical activity and breast cancer risk: the Women's Health Study (United States)

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Abstract

Objective: It is biologically plausible for physical activity to decrease breast cancer risk; however, epidemiologic studies have yielded inconsistent findings. We therefore examined physical activity and breast cancer risk in the Women's Health Study.

Methods: We assessed physical activity among 39,322 apparently healthy women, aged ≥45 years, and prospectively followed them for an average of 48 months. Four hundred eleven women developed breast cancer, with 222 positive for both estrogen and progesterone receptors.

Results: Among all women the multivariate relative risks of all breast cancer associated with <840, 840–2519, 2520–6299, and ≥6300 kJ/week expended on recreational activities and stair climbing were 1.00 (referent), 1.04 (95% confidence interval, 0.77–1.40), 0.86 (0.64–1.17), and 0.80 (0.58–1.12), respectively; p-trend = 0.11. However, among postmenopausal women there was a significant inverse trend for all breast cancer; the corresponding relative risks were 1.0 (referent), 0.97 (0.68–1.4), 0.78 (0.54–1.1), and 0.67 (0.44–1.0), respectively; p-trend = 0.03. Physical activity was unrelated to breast cancers positive for both estrogen and progesterone receptors either among all or postmenopausal women (p-trend = 0.50 and 0.26, respectively). When we assessed only vigorous recreational activity, requiring ≥6 METs or multiples of resting metabolic rate, we observed no significant associations with all or steroid hormone receptor positive breast cancer, either among all or postmenospausal women.

Conclusions: These data suggest that physical activity during middle age and older is not uniformly associated with decreased breast cancer risk. Among postmenopausal women only, higher levels of physical activity may decrease the risk of breast cancer. This study, however, had limited statistical power to detect small effects.

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References

  1. Landis AH, Murray T, Bolden S, Wingo PA (1999) Cancer statistics, 1999. CA Cancer J Clin 49: 8-31.

    Google Scholar 

  2. Kelsey JL, Bernstein L (1996) Epidemiology and prevention of breast cancer. Annu Rev Public Health 17: 47-67.

    Google Scholar 

  3. Collins FS (1996) BRCA1-Lots of mutations, lots of dilemmas. N Engl J Med 334: 186-188.

    Google Scholar 

  4. Bernstein L, Henderson BE, Hanisch R, Sullivan-Halley J, Ross RK (1994) Physical exercise and reduced risk of breast cancer in young women. J Natl Cancer Inst 86: 1403-1408.

    Google Scholar 

  5. Thune I, Brenn T, Lund E, Gaard M (1997) Physical activity and the risk of breast cancer. N Engl J Med 336: 1269-1275.

    Google Scholar 

  6. Friedenreich CM, Rohan TE (1995) A review of physical activity and breast cancer. Epidemiology 6: 311-317.

    Google Scholar 

  7. Kramer MM, Wells CL (1996) Does physical activity reduce risk of estrogen dependent cancer in women? Med Sci Sports Exerc 28: 322-334.

    Google Scholar 

  8. Gammon MD, John EM, Britton JA (1998) Recreational and occupational physical activities and risk of breast cancer. J Natl Cancer Inst 90: 100-117.

    Google Scholar 

  9. McTiernan A, Ulrich C, Slate S, Potter J (1998) Physical activity and cancer etiology: associations and mechanisms. Cancer Causes Control 9: 487-509.

    Google Scholar 

  10. Rockhill B, Willett WC, Hunter DJ, et al. (1998) Physical activity and breast cancer risk in a cohort of young women. J Natl Cancer Inst 90: 1155-1160.

    Google Scholar 

  11. Carpenter CL, Ross RK, Paganini-Hill A, Bernstein L (1999) Lifetime physical activity and breast cancer risk among post-menopausal women. Br J Cancer 80: 1852-1858.

    Google Scholar 

  12. Rockhill B, Willett WC, Hunter DJ, Manson JE, Hankinson SE, Colditz GA (1999) A prospective study of recreational physical activity and breast cancer risk. Arch Intern Med 159: 2290-2296.

    Google Scholar 

  13. Cumming DC, Vickovic MM, Wall SR, Fluker MR (1985) Defects in pulsatile LH release in normally menstruating runners. J Clin Endocrinol Metab 60: 810-812.

    Google Scholar 

  14. Loucks AB, Mortola JF, Girton L, Yen SS (1989) Alterations in the hypothalamic-pituitary-ovarian and the hypothalamic-pituitary-adrenal axes in athletic women. J Clin Endocrinol Metab 68: 402-411.

    Google Scholar 

  15. Fisher EC, Nelson ME, Frontera WR, Turksoy RN, Evans WJ (1986) Bone mineral content and levels of gonadotrophins and estrogens in amenorrheic running women. J Clin Endocrinol 62: 1232-1236.

    Google Scholar 

  16. Ellison PT, Lager C (1989) Moderate recreational running is associated with lower salivary progesterone profiles in women. Am J Obstet Gynecol 129: 1120-1131.

    Google Scholar 

  17. Cauley JA, Gutai JP, Kuller LH, LeDonne D, Powell JG (1989) The epidemiology of serum sex hormones in postmenopausal women. Am J Epidemiol 129: 1120-1131.

    Google Scholar 

  18. Frisch RE, Wyshak G, Vincent L (1980) Delayed menarche and amenorrhea in ballet dancers. N Engl J Med 303: 17-19.

    Google Scholar 

  19. Frisch RE, Gotz-Welbergen AV, McArthur JW, et al. (1981) Delayed menarche and amenorrhea of college athletes in relation to age of onset of training. JAMA 246: 1559-1563.

    Google Scholar 

  20. Bernstein L, Ross RK, Lobo RA, Hanisch R, Krailo MD, Henderson BE (1987) The effects of moderate physical activity on menstrual cycle patterns in adolescence: implications for breast cancer prevention. Br J Cancer 55: 681-685.

    Google Scholar 

  21. Hill JO, Saris WHM (1998) Energy expenditure in physical activity. In: Bray GA, Bouchard C, James WPT, eds. Handbook of Obesity. New York: Marcel Dekker, pp. 457-474.

    Google Scholar 

  22. Hoffmann-Goetz L, ed. (1996) Exercise and Immune Function. Boca Raton, FL: CRC Press.

    Google Scholar 

  23. Sternfeld B, Williams CS, Quesenberry CP, Satariano WA, Sidney S (1993) Lifetime physical activity and incidence of breast cancer. Med Sci Sports Exerc 25(5 suppl.): S148.

    Google Scholar 

  24. Buring JE, Hennekens CH (1992) The Women's Health Study: rationale and background. J Myocardial Ischemia 4: 30-40.

    Google Scholar 

  25. Buring JE, Hennekens CH (1992) The Women's Health Study: summary of the study design. J Myocardial Ischemia 4: 27-29.

    Google Scholar 

  26. Ainsworth BE, Haskell WL, Leon AS, et al. (1993) Compendium of physical activities: classiffication of energy costs of human physical activities. Med Sci Sports Exerc 25: 71-80.

    Google Scholar 

  27. Taylor HL, Jacobs DR Jr, Schucker B, Knudsen J, Leon AS, Debacker G (1978) A questionnaire for the assessment of leisure time physical activities. J Chron Dis 31: 741-755.

    Google Scholar 

  28. Bassett DR, Vachon JA, Kirkland AO, Howley ET, Duncan GE, Johnson KR (1997) Energy cost of stair climbing and descending on the college alumnus questionnaire. Med Sci Sports Exerc 29: 1250-1254.

    Google Scholar 

  29. Wolf AM, Hunter DJ, Colditz GA, et al. (1994) Reproducibility and validity of a self-administered physical activity questionnaire. Int J Epidemiol 23: 991-999.

    Google Scholar 

  30. Cox DR (1972) Regression models and life tables. J Roy Stat Soc (B) 34: 187-220.

    Google Scholar 

  31. Potter JD, Cerhan JR, Sellers TA, et al. (1995) Progesterone and estrogen receptors and mammary neoplasia in the Iowa Women's Health Study: how many kinds of breast cancer are there? Cancer Epidemiol Biomarkers Prev 4: 319-326.

    Google Scholar 

  32. Dosemeci M, Hayes RB, Vetter R, et al. (1993) Occupational physical activity, socioeconomic status, and risk of 15 cancer sites in Turkey. Cancer Causes Control 4: 313-321.

    Google Scholar 

  33. Dorgan JF, Brown C, Barrett M, et al. (1994) Physical activity and risk of breast cancer in the Framingham Heart Study. Am J Epidemiol 139: 662-669.

    Google Scholar 

  34. Sesso HD, Paffenbarger RS Jr, Lee I-M (1998) Physical activity and breast cancer risk in the College Alumni Health Study. Cancer Causes Control 9: 433-439.

    Google Scholar 

  35. Rexrode KM, Lee I-M, Cook NR, Hennekens CH, Buring JE (2000) Baseline characteristics of participants in the Women's Health Study. J Womens Health 9: 19-27.

    Google Scholar 

  36. Newcomb PA, Klein R, Klein BEK, et al. (1995) Association of dietary and life-style factors with sex hormones in postmenopausal women. Epidemiology 6: 318-321.

    Google Scholar 

  37. Drent ML (1998) Effects of obesity on endocrine function. In: Bray GA, Bouchard C, James WPT, eds. Handbook of Obesity. New York: Marcel Dekker, pp. 753-774.

    Google Scholar 

  38. Hankinson SE, Willett WC, Manson JE, et al. (1998) Plasma sex steroid hormone levels and risk of breast cancer in postmenopausal women. J Natl Cancer Inst 90: 1292-1299.

    Google Scholar 

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Lee, IM., Rexrode, K.M., Cook, N.R. et al. Physical activity and breast cancer risk: the Women's Health Study (United States). Cancer Causes Control 12, 137–145 (2001). https://doi.org/10.1023/A:1008948125076

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