1932
0
  1. Home
  2. A-Z Publications
  3. Annual Review of Pharmacology and Toxicology
  4. Volume 38, 1998
  5. Article

Annual Review of Pharmacology and Toxicology

Volume 38, 1998

A QUEST FOR ERYTHROPOIETIN OVER NINE DECADES

Abstract

▪  

The major research accomplishments of the author are described from the time of his PhD thesis work on the mechanism of cobalt polycythemia to the present day. His early work on the quest for the cell that produces erythropoietin (Epo) to his current work on oxygen sensing and signal transduction pathways involved in erythropoietin gene expression are reported. He describes his main research interest in the mechanism of cobalt polycythemia between 1954 and 1962 and his research on how hormones such as the glucocorticoids function in the regulation of erythropoiesis (1956–1962). His major findings during this period were the discovery that hydrocortisone and corticosterone stimulated erythropoiesis (1958) and that cobalt increased erythropoietin production in the isolated perfused dog kidney (1961). He describes how he was led astray in some of his early studies on the cells in the kidney that produce erythropoietin, because of the less-developed technology available to him at that time; and how in situ hybridization and other molecular biology techniques enabled him to confirm some of the earlier work in mice by other investigators that interstitial cells in the kidney were the site of production of erythropoietin in the primate. His work in the controversial area of the mechanism of the anemia of end-stage renal disease is described in detail, as it pertains to Epo deficiency and suppressed erythroid progenitor cell response to Epo. He also discusses his recent work on signal transduction pathways (hypoxia, nitric oxide, adenosine, and C kinase) in oxygen sensing and Epo gene expression.

Keyword(s): adenosine, Autobiography, cobalt, hydrocortisone, hypoxia, kidney
Loading

Article metrics loading...

/content/journals/10.1146/annurev.pharmtox.38.1.1
1998-04-01
2024-04-16
Loading full text...

Full text loading...

/deliver/fulltext/pharmtox/38/1/annurev.pharmtox.38.1.1.html?itemId=/content/journals/10.1146/annurev.pharmtox.38.1.1&mimeType=html&fmt=ahah

Literature Cited

  1. Carnot P, DeFlandre C. 1906. Sur l'activité hématopoiétique des différents organes au cours de la régénération du sang.. C. R. Acad. Sci. Paris 143:432–35 [Google Scholar]
  2. Hjort E. 1936. Reticulocyte increase after injection of anemic serum.. Norsk. Mag. F. Laegevidensk. 97:270–77 [Google Scholar]
  3. Fisher JW. 1992. Forward. Pathophysiology and Pharmacology of Erythropoietin, ed. H Pagel, C Weiss, W Jelkmann v–vii Berlin/Heidelberg: Springer-Verlag
  4. Krumdieck N. 1943. Erythropoietic substance in the serum of anemic animals.. Proc. Soc. Exp. Biol. 54:14–17 [Google Scholar]
  5. Erslev AJ. 1953. Humoral regulation of red cell production.. Blood 8:349–57 [Google Scholar]
  6. Reissmann KR. 1950. Studies on the mechanism of erythropoietic stimulation in parabiotic rats during hypoxia.. Blood 5:372–80 [Google Scholar]
  7. Bonsdorff E, Jalavisto E. 1948. A humoral mechanism in anoxic erythrocytosis.. Acta. Physiol. Scand. 16:150–70 [Google Scholar]
  8. Miyake T, Kung CK-H, Goldwasser E. 1977. Purification of human erythropoietin.. J. Biol. Chem. 252:5558–64 [Google Scholar]
  9. Lin FK, Suggs S, Lin CH, Browne JK, Smalling R. et al. 1985. Cloning and expression of the human erythropoietin gene.. Proc. Natl. Acad. Sci. USA 82:7580–84 [Google Scholar]
  10. Waltner K, Waltner K. 1929. Kobalt und Blut.. Klin. Woch. 8:313 [Google Scholar]
  11. Weissbecker L. 1950. Die Kabalttherapie.. Dtsch. Med. Wochenschrift. 75:116–18 [Google Scholar]
  12. Fisher JW. 1958. Increase in circulating red cell volume of normal rats after treatment with hydrocortisone or corticosterone.. Proc. Soc. Exp. Biol. Med. 97:502–5 [Google Scholar]
  13. Fisher JW, Roh BL, Halvorsen S. 1967. Inhibition of erythropoietic effects of hormones by erythropoietin antisera in mildly plethoric mice.. Proc. Soc. Exp. Biol. Med. 126:97–100 [Google Scholar]
  14. Jacobson LO, Goldwasser E, Fried W, Plzak L. 1957. Role of the kidney in erythropoiesis.. Nature 179:633 [Google Scholar]
  15. Goldwasser E, Jacobson LO, Fried W, Plzak L. 1957. Mechanism of the erythropoietic effect of cobalt.. Science 125:1085 [Google Scholar]
  16. Jacobson LO, Marks E, Gaston O, Robson M, Zirkle RE. 1949. The role of the spleen in radiation injury.. Proc. Soc. Exp. Biol. Med. 70:740–42 [Google Scholar]
  17. Fisher JW, Birdwell BJ. 1961. Erythropoietin production by the in situ perfused kidney.. Fed. Proc. 20:68 [Google Scholar]
  18. Fisher JW, Birdwell BJ. 1961. The production of erythropoietic factor by the in situ perfused kidney.. Acta Haematol. 26:224–32 [Google Scholar]
  19. Kuratowska Z, Lewartowski B, Michalski E. 1961. Studies on the production of erythropoietin by isolated perfused organs.. Blood 18:527–34 [Google Scholar]
  20. Erslev AJ, Solit RW, Camishion RC, Amsel S, Ilda J. et al. 1965. Erythropoietin in vitro. III. Perfusion of a lung-kidney preparation.. Am. J. Physiol. 208:11253–57 [Google Scholar]
  21. Fisher JW, Langston JW. 1967. The influence of hypoxemia and cobalt on erythropoietin production in the isolated perfused dog kidney.. Blood 29(1):114–25 [Google Scholar]
  22. Reissmann KR, Nomura T. 1962. Erythropoietin formation in isolated kidneys and liver. In Erythropoiesis, ed. LO Jacobson, M Doyl 71–77 New York: Grune & Stratton
  23. Zangheri EO, Campana H, Ponce F, Silva JC, Fernandez FO. et al. 1963. Production of erythropoietin by anoxic perfusion of the isolated kidney of a dog.. Nature 199:572–73 [Google Scholar]
  24. Erslev AJ. 1974. In vitro production of erythropoietin by kidneys perfused with a serum-free solution.. Blood 44:77–85 [Google Scholar]
  25. Fisher JW, Taylor G, Porteus DD. 1965. Localization of erythropoietin in glomeruli of sheep kidney by fluorescent antibody technique.. Nature 205:611–12 [Google Scholar]
  26. Jacobs K, Shoemaker C, Rudersdorf R, Neill SD, Kaurman RJ. et al. 1985. Isolation and characterization of genomic and cDNA clones of human erythropoietin.. Nature 313:806–10 [Google Scholar]
  27. Fisher JW. Consult. ed 1968. Monograph on Erythropoietin.. Ann. NY Acad. Sci. 149:1–583 [Google Scholar]
  28. Gordon AS, Cooper GW, Zanjani ED. 1967. The kidney and erythropoiesis.. Semin. Hematol. 4:337–58 [Google Scholar]
  29. Koury ST, Bondurant MC, Koury MJ. 1988. Localization of erythropoietin synthesizing cells in murine kidneys by in situ hybridization.. Blood 71:524–27 [Google Scholar]
  30. Lacombe C, DaSilva JL, Bruneval P, Fournier JG, Wendling F. et al. 1988. Peritubular cells are the site of erythropoietin synthesis in the murine hypoxic kidney.. J. Clin. Invest. 81:620–23 [Google Scholar]
  31. Busuttil RW, Roh BL, Fisher JW. 1972. Further evidence for the production of erythropoietin in the dog kidney.. Acta Haematol. 47:238–42 [Google Scholar]
  32. Busuttil RW, Roh BL, Fisher JW. 1971. The cytological localization of erythropoietin in the human kidney using the fluorescent antibody technique.. Proc. Soc. Exp. Biol. Med. 137:327–30 [Google Scholar]
  33. Fisher JW, Koury S, Ducey T, Mendel S. 1996. Erythropoietin production by interstitial cells of hypoxic monkey kidneys.. Br. J. Haematol. 95:27–32 [Google Scholar]
  34. Fisher JW, Crook JJ. 1962. Influence of several hormones on erythropoiesis and oxygen consumption in the hypophysectomized rat.. Blood 19:557–65 [Google Scholar]
  35. Malgor LA, Fisher JW. 1969. Antagonism of angiotensin by hydralazine on renal blood flow and erythropoietin production.. Am. J. Physiol. 316:563–66 [Google Scholar]
  36. Fisher JW, Samuels AI, Langston JW. 1967. Effects of angiotension and renal artery constriction on erythropoietin production.. J. Pharmacol. Exp. Ther. 157:618–25 [Google Scholar]
  37. Anagnostou A, Baronowski R, Pillay KG, Vercelloti G, Fried W. 1976. Effect of renin on extrarenal erythropoietin production.. J. Lab. Clin. Med. 88:707–15 [Google Scholar]
  38. Garcia MM, Brookins JW, Powell JS, Lanham W, Blaisdell S. et al. 1990. Development of a new radioimmunoassay for Epo using recombinant erythropoietin.. Kidney Int. 38:969–75 [Google Scholar]
  39. Eschbach JW, Haley NR, Egrie JC, Adamson JW. 1992. A comparison of the response to recombinant human erythropoietin in normal and uremic subjects.. Kidney Int. 42:407–16 [Google Scholar]
  40. Moriyama Y, Lertora JJL, Fisher JW. 1974. Studies on an inhibitor of erythropoiesis. I. Effects of sera from normal and polycythemic rabbits on heme synthesis in rabbit bone marrow culture.. Proc. Soc. Exp. Biol. Med. 147:740–43 [Google Scholar]
  41. Fisher JW, Moriyama Y, Lertora JJL. 1975. Mechanisms of androgen stimulated erythropoiesis and inhibitors of heme synthesis in uremia.. Blood Cells 1:573–97 [Google Scholar]
  42. McGonigle RJS, Boineau FG, Ohene-Frempong K, Lewy JE, Shadduck RK. et al. 1985. Erythropoietin and inhibitors of in vitro erythropoiesis in the development of anemia in children with renal disease.. J. Lab. Clin. Med. 105:449–81 [Google Scholar]
  43. Radtke HW, Rege AB, LaMarche MB, Bartos D, Campbell RA. et al. 1980. Identification of spermine as an inhibitor of erythropoiesis in patients with chronic renal failure.. J. Clin. Invest. 67:1623–29 [Google Scholar]
  44. Kushner DS, Beckman BS, Fisher JW. 1989. Do polyamines play a role in the pathogenesis of the anemia of end stage renal disease?. Kidney Int. 36:171–74 [Google Scholar]
  45. Kushner D, Beckman B, Nguyen L, Chen S, Santina D. et al. 1991. Polyamines in the anemia of end stage renal disease (ESRD).. Kidney Int. 39:725–32 [Google Scholar]
  46. Erslev AJ, Besarab A. 1995. The rate and control of baseline red cell production in hematologically stable patients with uremia.. J. Lab. Clin. Med. 126(3):283–86 [Google Scholar]
  47. Steiner RW. 1984. Characteristics of the hematocrit response to continuous ambulatory dialysis.. Arch. Intern. Med. 144:728–32 [Google Scholar]
  48. McGonigle RJS, Husserl F, Wallin JD, Fisher JW. 1984. Hemodialysis and continuous ambulatory peritoneal dialysis effects on erythropoiesis in renal failure.. Kidney Int. 25:430–36 [Google Scholar]
  49. Ohigashi T, Brookins, Fisher JW. 1993. Interaction of nitric oxide and cyclic GMP in erythropoietin production.. J. Clin. Invest. 92:1587–91 [Google Scholar]
  50. Rodgers GM, George WJ, Fisher JW. 1972. Increased kidney cyclic AMP levels and erythropoietin production following cobalt administration.. Proc. Soc. Exp. Biol. Med. 140:977–81 [Google Scholar]
  51. Rodgers GM, Fisher JW, George WJ. 1975. The role of renal adenosine 3′,5′-monophosphate in the control of erythropoietin production.. Am. J. Med. 58:31–38 [Google Scholar]
  52. Ueno M, Seferynska IL, Beckman B, Brookins J, Nakashima J. et al. 1989. Enhanced erythropoietin secretion in hepatoblastoma cells in response to hypoxia.. Am. J. Physiol. 257(26):C743–49 [Google Scholar]
  53. Nakashima J, Brookins J, Beckman G, Fisher JW. 1991. Characterization of erythropoietin production in a hepatocellular carcinoma cell line.. Am. J. Physiol. 261(30):C455–60 [Google Scholar]
  54. Fink GD, Fisher JW. 1977. Stimulation of erythropoiesis by beta adrenergic agonists. I. Characterization of activity in polycythemic mice.. J. Pharmacol. Exp. Ther. 202:192–98 [Google Scholar]
  55. Fink GD, Fisher JW. 1977. Stimulation of erythropoiesis by beta adrenergic agonists. II. Mechanism of action.. J. Pharmacol. Exp. Ther. 202:199–208 [Google Scholar]
  56. Fink GD, Fisher JW. 1976. Erythropoietin production after renal denervation or beta-adrenergic blockade.. Am. J. Physiol. 230:508–13 [Google Scholar]
  57. Jelkmann W, Beckman B, Fisher JW. 1979. Enhanced effects of hypoxia on erythropoiesis in rabbits following beta-2 adrenergic activation with albuterol.. J. Pharmacol. Exp. Ther. 211:99–103 [Google Scholar]
  58. Jelkmann W, Brookins J, Fisher JW. 1979. Indomethacin blockade of albuterol-induced erythropoietin production in isolated perfused dog kidneys.. Proc. Soc. Exp. Biol. Med. 162:65–70 [Google Scholar]
  59. Gross DM, Brookins J, Fink GD, Fisher JW. 1976. Effects of prostaglandins A2, E2 and F2α on erythropoietin production.. J. Pharmacol. Exp. Ther. 198:489–96 [Google Scholar]
  60. Mujovic VM, Fisher JW. 1974. The effects of indomethacin on erythropoietin production in dogs following renal artery constriction. I. The possible role of prostaglandins in the generation of erythropoietin by the kidney.. J. Pharmacol. Exp. Ther. 191:575–80 [Google Scholar]
  61. Nelson PK, Brookins J, Fisher JW. 1983. Erythropoietic effects of prostacyclin (PGI2) and its metabolite 6-keto-prosta-glandin (PG)E1.. J. Pharmacol. Exp. Ther. 226(2):493–99 [Google Scholar]
  62. Paulo LG, Wilkerson RD, Roh BL, George WJ, Fisher JW. 1973. The effects of prostaglandins E1 on erythropoietin production.. Proc. Soc. Exp. Biol. Med. 142:771–75 [Google Scholar]
  63. Ohigashi T, Nakashima J, Aggarwal S, Brookins J, Agrawal K. et al. 1995. Enhancement of erythropoietin production by selective adenosine A2 receptor agonists in response to hypoxia.. J. Lab. Clin. Med. 126:299–306 [Google Scholar]
  64. Nakashima J, Brookins J, Ohigashi T, Fisher JW. 1993. Adenosine A2 receptor modulation of erythropoietin secretion in hepatocellular carcinoma cells.. Life Sci. 54(2):109–17 [Google Scholar]
  65. Bakris GR, Sauter ER, Hussey JL, Fisher JW, Gaber AO. et al. 1990. Effects of theophylline on erythropoietin production in normal subjects and in patients with erythrocytosis after renal transplantation.. N. Engl. J. Med. 323:86–90 [Google Scholar]
  66. Faquin WC, Schneider TJ, Goldberg MA. 1993. Modulators of protein kinase C inhibit hypoxia-induced erythropoietin production.. Exp. Hematol. 21:420–26 [Google Scholar]
  67. Hagiwara M, Nagakura K, Fisher JW. 1987. Inhibitory effects of tetradecanoyl-phorbol acetate and diacylglycerol on erythropoietin production in human renal carcinoma cell cultures.. Exp. Cell. Res. 173:129–36 [Google Scholar]
  68. Jelkmann W, Hurwiler A, Fandrey J, Pfelschifter J. 1991. Inhibition of erythropoietin production by phorbol ester is associated with down-regulation of protein kinase C-α isoenzyme in hepatoma cells.. Biochem. Biophys. Res. Commun. 179:1441 [Google Scholar]
/content/journals/10.1146/annurev.pharmtox.38.1.1
Loading
A QUEST FOR ERYTHROPOIETIN OVER NINE DECADES
Annual Review of Pharmacology and Toxicology 38, 1 (1998); https://doi.org/10.1146/annurev.pharmtox.38.1.1
/content/journals/10.1146/annurev.pharmtox.38.1.1
/content/journals/10.1146/annurev.pharmtox.38.1.1
Loading

Data & Media loading...

  • Article Type: Review Article

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error