Chest
Clinical InvestigationsEXERCISEAcute Effects of Exercise in Patients With Previous Deep Venous Thrombosis*: Impact of the Postthrombotic Syndrome
Section snippets
Subjects
Study subjects were recruited from the Thrombosis Clinic of our hospital, a clinic that observes all patients in whom venous thromboembolism had been diagnosed. Sequential patients with a first diagnosis of unilateral DVT established by objective testing at least 1 year prior were approached for participation in the study. Subjects were excluded if they had bilateral DVT, had experienced more than one episode of DVT, had symptomatic pulmonary embolism, had any medical condition that precluded
Study Population
Forty-three patients were recruited over a 1-year period (1999 to 2000). Two patients were excluded (one had a history of bilateral DVT and one was not able to follow the research assistant’s instructions), leaving a study population of 41 subjects. PTS, as defined as a Villalta score of ≥ 5, was present in 19 patients (46.3%) in the study group, and the PTS was categorized as mild/moderate in 17 subjects and as severe in 2 subjects. The mean (SD) PTS score was 2.1 (1.3), 6.4 (1.3), and 19.0
Discussion
DVT and its chronic sequela, PTS, affect adults of all age groups, many of whom are active and eager to exercise. The effects of exercise on patients with DVT and PTS have not been studied previously. From a physiologic point of view, exercise could either help or worsen PTS. During exercise, muscle contraction increases the pressure outside of the veins and propels blood back to the heart (calf muscle pump), reducing the hydrostatic pressure gradient required for edema formation.16 However,
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Cited by (26)
Exercise social support, barriers, and instructions in venous thromboembolism survivors: a descriptive study
2023, Research and Practice in Thrombosis and HaemostasisPhysical activity in children at risk of postthrombotic sequelae: A pilot randomized controlled trial
2020, Blood AdvancesCitation Excerpt :Post-pulmonary embolism (post-PE) syndrome, characterized by persistent dyspnea, impaired exercise capacity, and decreased quality of life (QoL), affects ≤50% of patients surviving PE.6,7 Both PTS and post-PE syndrome are associated with decreased physical activity levels.3,8 Exercise training after an acute VTE is safe but underutilized.9-11
Reduced Physical Activity Levels in Children after a First Episode of Acute Venous Thromboembolism
2020, Journal of PediatricsCitation Excerpt :Higher leisure time scores indicate increased physical activity and reflect physical activity that is likely to be more volitional and performed at higher intensity compared with the household or occupational physical activity.18 We used the Godin questionnaire because it has been extensively used in patients with DVT in prior studies, and test-retest reliability (r = 0.81), and the validity of physical activity recall are high in children as young as the fifth grade.4,6,19,20 Individuals reporting moderate-to-strenuous activity levels of ≥24 are classified as active, whereas individuals reporting moderate-to-strenuous activity levels of ≤23 are classified as insufficiently active.
Pediatric venous thromboembolism in relation to adults
2012, Journal of Vascular SurgeryCitation Excerpt :The established therapy for PTS includes the use of compression stockings, limb elevation, avoidance of prolonged standing, and early ambulation. Weight loss and mild exercise have recently been investigated as therapy for PTS.94,95 As seen in adults, compliance with compression stockings is problematic in children because they dislike displaying visible signs of a disability that make them vulnerable to criticism from their peers.
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Drs. Kahn and Shrier are Chercheurs Boursier Clinicien (Clinical Research Scholars) supported by the Fonds de Recherche en Santé du Québec. This study was supported by an unrestricted grant-in-aid from the Beiersdorf-Jobst Research Program of the American College of Phlebology.