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Resistance Exercise Overtraining and Overreaching

Neuroendocrine Responses

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Summary

Overtraining is defined as an increase in training volume and/or intensity of exercise resulting in performance decrements. Recovery from this condition often requires many weeks or months. A shorter or less severe variation of overtraining is referred to as overreaching, which is easily recovered from in just a few days. Many structured training programmes utilise phases of overreaching to provide variety of the training stimulus. Much of the scientific literature on overtraining is based on aerobic activities, despite the fact that resistance exercise is a large component of many exercise programmes. Chronic resistance exercise can result in differential responses to overtraining depending on whether either training volume or training intensity is excessive. The neuroendocrine system is a complex physiological entity that can influence many other systems. Neuroendocrine responses to high volume resistance exercise overtraining appear to be somewhat similar to overtraining for aerobic activities. On the other hand, excessive resistance training intensity produces a distinctly different neuroendocrine profile. As a result, some of the neuroendocrine characteristics often suggested as markers of overtraining may not be applicable to some overtraining scenarios. Further research will permit elucidation of the interactions between the neuroendocrine system and other physiological systems in the aetiology of performance decrements from overtraining.

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References

  1. Fry AC, Kraemer WJ, van Borselen F, et al. Performance decrements with high-intensity resistance exercise overtraining. Med Sci Sports Exerc 1994; 26(9): 1165–73

    PubMed  CAS  Google Scholar 

  2. O’Connor PJ, Morgan WP, Raglin JS, et al. Selected psychoendocrine responses to overtraining [abstract]. Med Sci Sports Exerc 1989; 21 Suppl. 2: S50

    Google Scholar 

  3. Bourguignon J-P, Hoyoux C, Reuter A, et al. Urinary excretion of immunoreactive luteinizing hormone-releasing hormone-like material and gonadotropins at different stages of life. J Clin Endocrinol Metab 1979; 48: 78–84

    PubMed  CAS  Google Scholar 

  4. Fellman N, Bedu M, Boudet G, et al. Inter-relationships between pituitary-adrenal hormones and catecholamines during a 6-day Nordic ski race. Eur J Appl Physiol 1992; 64: 258–65

    Google Scholar 

  5. Lehmann M, Gastmann U, Petersen KG, et al. Training-overtraining: performance, and hormone levels, after a defined increase in training volume versus intensity in experienced middle- and long-distance runners. Br J Sports Med 1992; 26: 233–42

    PubMed  CAS  Google Scholar 

  6. Stone MH, Keith RE, Kearney JT, et al. Overtraining: a review of the signs, symptoms and possible causes. J Appl Sports Sci Res 1991; 5(1): 35–50

    Google Scholar 

  7. Adlercreutz H, Härkönen M, Kuoppasalmi K, et al. Effect of training on plasma anabolic and catabolic steroid hormones and their response during physical exercise. Int J Sports Med 1986; 7 Suppl.: 27–8

    PubMed  CAS  Google Scholar 

  8. Budgett R. Overtraining syndrome. Br J Sports Med 1990; 24(4): 231–6

    PubMed  CAS  Google Scholar 

  9. Lehmann M, Dickhuth H, Gendrisch G, et al. Training-overtraining. A prospective, experimental study with experienced middle- and long-distance runners. Int J Sports Med 1991; 12(5): 444–52

    CAS  Google Scholar 

  10. Hooper SL, MacKinnon LT, Gordon RD, et al. Hormonal responses of elite swimmers to overtraining. Med Sci Sports Exerc 1993; 25: 741–7

    PubMed  CAS  Google Scholar 

  11. Lehmann M, Foster C, Keul J. Overtraining in endurance athletes: a brief review. Med Sci Sports Exerc 1993; 25: 854–62

    PubMed  CAS  Google Scholar 

  12. Kindermann W. Overtraining — Expression of a disturbed autonomic regulation. Dtsch Z Sportmed 1986; 37: 238–45

    Google Scholar 

  13. Kirwan JP, Costill DL, Flynn MG, et al. Physiological responses to successive days of intense training in competitive swimmers. Med Sci Sports Exerc 1988; 20(3): 255–9

    PubMed  CAS  Google Scholar 

  14. Stray-Gunderson J, Videman T, Snell PG. Changes in selected objective parameters during overtraining [abstract]. Med Sci Sports Exerc 1986; 18 Suppl. 2: S54–5

    Google Scholar 

  15. Urhausen, A, Gabriel H, Kindermann W. Blood hormones as markers of training stress and overtraining. Sports Med 1995; 20(4): 251–76

    PubMed  CAS  Google Scholar 

  16. Kuipers H, Keizer HA. Overtraining in elite athletes, review and directions for the future. Sports Med 1988; 6: 79–92

    PubMed  CAS  Google Scholar 

  17. Jeukendrup AE, Hesselink MK. Overtraining — what do lactate curves tell us? Br J Sports Med 1994; 28(4): 239–40

    PubMed  CAS  Google Scholar 

  18. Fry RW, Morton AR, Keast D. Overtraining in athletes, an update. Sports Med 1991; 12(1): 32–65

    PubMed  CAS  Google Scholar 

  19. Vervoorn C. Neuro-endocrine aspects of exercise and training. Utrecht: Elinkwijk B.V., 1992

    Google Scholar 

  20. Häkkinen K, Keskinen KL, Alén M, et al. Serum hormone concentrations during prolonged training in elite endurance-trained and strength-trained athletes. Eur J Appl Physiol 1989; 59: 233–8

    Google Scholar 

  21. Busso T, Häkkinen K, Pakarinen A, et al. A systems model of training responses and its relationship to hormonal responses in elite weight-lifters. Eur J Appl Physiol 1990; 61: 48–54

    CAS  Google Scholar 

  22. Fry AC, Kraemer WJ, Stone MH, et al. Endocrine responses to overreaching before and after 1 year of weightlifting. Can J Appl Physiol 1994; 19(4): 400–10

    PubMed  CAS  Google Scholar 

  23. Fry AC, Kraemer WJ, Stone MH, et al. Endocrine and performance responses to high volume training and amino acid supplementation in elite junior weightlifters. Int J Sports Nutr 1993; 3: 306–22

    CAS  Google Scholar 

  24. Fry AC, Kraemer WJ, Stone MH, et al. Endocrine and performance responses during one month of periodized weightlifting with amino acid supplementation [abstract]. J Appl Sport Sci Res 1992; 6(3): 183

    Google Scholar 

  25. Fry AC, Kraemer WJ, Lynch JM, et al. Does short-term near-maximal intensity machine resistance exercise induce overtraining? J Str Cond Res 1994; 8(3): 188–91

    Google Scholar 

  26. Häkkinen K, Pakarinen A, Alén M, et al. Relationships between training volume, physical performance capacity, and serum hormone concentrations during prolonged training in elite weight lifters. Int J Sports Med 1987; Suppl. 8: 61–5

    Google Scholar 

  27. Häkkinen K, Pakarinen A, Alén M, et al. Daily hormonal and neuromuscular responses to intensive strength training in 1 week. Int J Sports Med 1988; 9(6): 422–8

    PubMed  Google Scholar 

  28. Brown RL, Frederick EC, Falsetti HL, et al. Overtraining of athletes — a round table. Phys Sports Med 1983; 11(6): 93–110

    Google Scholar 

  29. Callister R, Callister RJ, Fleck SJ, et al. Physiological and performance responses to overtraining in elite judo athletes. Med Sci Sports Exerc 1990; 22(6): 816–24

    PubMed  CAS  Google Scholar 

  30. Morgan WP, Brown DR, Raglin JS, et al. Psychological monitoring of overtraining and staleness. Br J Sports Med 1987; 21(3): 107–14

    PubMed  CAS  Google Scholar 

  31. Newsholme EA, Blomstrand E, McAndrew N, et al. Biochemical causes of fatigue and overtraining. In: Shepherd RJ, Åstrand P-O, editors. Endurance in Sports. London: Black-well Scientific Publications, 1992: 351–64

    Google Scholar 

  32. Selye H. The Stress of Life. New York: McGraw-Hill, 1956

    Google Scholar 

  33. van Borselen F, Vos NH, Fry AC, et al. The role of anaerobic exercise in overtraining. Natl Str Cond Assoc J 1992; 14(3): 74–9

    Google Scholar 

  34. Parry-Billings M, Blomstrand F, McAndrew N, et al. A communicational link between skeletal muscle, brain, and cells of the immune system. Int J Sports Med 1990; 11 Suppl. 2: S122–8

    PubMed  Google Scholar 

  35. Hagerman FC. Failing to adapt to training. FISA Coach 1992; 3(1): 1–4

    Google Scholar 

  36. Israel S. The problems of overtraining with reference to performance physiology and internal medicine [in German]. Med Sport 1976; 16(1): 1–12

    Google Scholar 

  37. Costill DL, Thomas R, Robergs RA, et al. Adaptations to swimming training: influence of training volume. Med Sci Sports Exerc 1991; 23(3): 371–7

    PubMed  CAS  Google Scholar 

  38. Dressendorfer RH, Wade CE, Scaff JH. Increased morning heart rate in runners: a valid sign of overtraining? Phys Sportsmed 1985; 13(8): 77–86

    Google Scholar 

  39. Flynn MG, Pizza FX, Andres FF, et al. Indices of training stress during competitive running and swimming seasons. Int J Sports Med 1994; 15: 21–6

    PubMed  CAS  Google Scholar 

  40. Griffith RO, Dressendorfer RH. Effects of overwork on testosterone, sperm count, and libido [abstract]. Med Sci Sports Exerc 1988; 20(2): S39

    Google Scholar 

  41. Grumbach MM, Roth JC, Kaplan SL. Hypothalamic-pituitary regulation of puberty in man: evidence and concepts derived from clinical research. In: Grumbach MM, Grave GD, Mayer FE, editors. Control of the onset of puberty. New York: John Wiley and Sons, 1974: 115–66

    Google Scholar 

  42. Lehmann M, Dickhuth H, Lazar W, et al. Four weeks overtraining study in long-distance runners [abstract]. FIMS World Congress of Sports Medicine: 1990; Amsterdam

  43. Lehmann M, Jakob E, Dickhuth H-H, et al. Sympathetic activity in relation to performance diagnostics, training and overtraining [abstract]. Int J Sports Med 1988; 9: 390–1

    Google Scholar 

  44. Sutton JR, Farrell PA, Harber VJ. Hormonal adaptation to physical activity. In: Bouchard C, Shephard RJ, Stephens T, et al., editors. Exercise, fitness and health. Champaign (IL): Human Kinetics Publishers, 1990: 217–63

    Google Scholar 

  45. Kame VD, Pendergast DR, Termin, B. Physiologic responses to high intensity training in competitive university swimmers. J Swimming Res 1990; 6(4): 5–8

    Google Scholar 

  46. Fry AC, Kraemer WJ, van Borselen F, et al. Catecholamine responses to short-term high-intensity resistance exercise overtraining. J Appl Physiol 1994; 77(2): 941–6

    PubMed  CAS  Google Scholar 

  47. Fry AC, Kraemer WJ, van Borselen F, et al. Endocrine responses to short-term intensity-specific resistance exercise overtraining [abstract]. J Str Cond Res 1993; 7(3): 179

    Google Scholar 

  48. Fry AC, Ramsey LT, Kraemer WJ, et al. Plasma proenkephalin peptide F responses to short-term high-intensity resistance exercise overtraining. Eur J Appl Physiol. In press

  49. Costill DL, Flynn MG, Kirwan JP, et al. Effects of repeated days of intensified training on muscle glycogen and swimming performance. Med Sci Sports Exerc 1988; 20(3): 249–54

    PubMed  CAS  Google Scholar 

  50. Fleck SJ, Kraemer WJ. Designing resistance exercise programmes. Champaign (IL): Human Kinetics Publishers, 1987

    Google Scholar 

  51. Galbo H. Hormonal and metabolic adaptation to exercise. Stuttgart: Georg Thieme Verlag, 1983

    Google Scholar 

  52. Galbo H. Endocrine factors in endurance. In: Shepherd RJ, Åstrand P-O, editors. Endurance in sports. London: Blackwell Scientific Publications, 1992: 116–26

    Google Scholar 

  53. Kraemer WJ. Endocrine responses to resistance exercise. Med Sci Sports Exerc 1988: 20 Suppl. 5: S152–7

    PubMed  CAS  Google Scholar 

  54. Kraemer WJ. Endocrine responses and adaptations to strength training. In: Komi PV, editor. Strength and power in sport. London: Blackwell Scientific Publications, 1992: 291–304

    Google Scholar 

  55. Kraemer WJ, Patton JF, Gordon SE, et al. Compatibility of high-intensity strength and endurance training on hormonal and skeletal muscle adaptations. J Appl Physiol 1995; 78(3): 976–89

    PubMed  CAS  Google Scholar 

  56. Kraemer WJ, Patton JF, Knuttgen HG, et al. Effects of high-intensity cycle exercise on sympathoadrenal-medullary response patterns. J Appl Physiol 1991; 70(1): 8–14

    PubMed  CAS  Google Scholar 

  57. Wheeler GD, Wall SR, Beicastro AN, et al. Reduced serum testosterone and prolactin levels in male distance runners. J Am Med Assoc 1984; 252: 514–6

    CAS  Google Scholar 

  58. Kraemer WJ, Gordon SE, Fleck SJ, et al. Endogenous anabolic hormonal and growth factor responses to heavy resistance exercise in males and females. Int J Sports Med 1991; 12(2): 228–35

    PubMed  CAS  Google Scholar 

  59. Kraemer WJ, Marchitelli L, Gordon SE, et al. Hormonal and growth factor responses to heavy resistance exercise protocols. J Appl Physiol 1990; 69(4): 1442–50

    PubMed  CAS  Google Scholar 

  60. Kraemer WJ, Fry AC, Warren BJ, et al. Acute hormonal responses in elite junior weightlifters. Int J Sports Med 1992; 13(20): 103–9

    PubMed  CAS  Google Scholar 

  61. McMillan JL, Stone MH, Sartin J, et al. 20-hour physiological responses to a single weight-training session. J Str Cond Res 1993; 7(1): 9–21

    Google Scholar 

  62. Alén M, Pakarinen A, Häkkinen K, et al. Responses of serum androgenic-anabolic and catabolic hormones to prolonged strength training. Int J Sports Med 1988; 9(3): 229–33

    PubMed  Google Scholar 

  63. Häkkinen K, Pakarinen A, Alén M, et al. Neuromuscular and hormonal adaptations in athletes to strength training in two years. J Appl Physiol 1988; 65(6): 2406–12

    PubMed  Google Scholar 

  64. Martini L, Celotti F, Lechuga MJ, et al. Androgen metabolism in different target tissues. Ann NY Acad Sci 1990; 595: 184–98

    PubMed  CAS  Google Scholar 

  65. Silva NL, Boulant JA. Effects of testosterone, estradiol, and temperature on neurons in preoptic tissue slices. Am J Physiol 1986; 19: R625–32

    Google Scholar 

  66. Kjaer M, Farrell PA, Christensen NJ, et al. Increased epinephrine response and inaccurate glucoregulation in exercising athletes. J Appl Physiol 1986; 61(5): 1693–1700

    PubMed  CAS  Google Scholar 

  67. Péronnet F, Cléroux J, Perrault H, et al. Plasma norepinephrine response to exercise before and after training in humans. J Appl Physiol 1981; 51(4): 812–5

    PubMed  Google Scholar 

  68. Fry AC, Kraemer WJ, Koziris LP, et al. The effect of chronic training on plasma dopamine concentrations during acute resistance exercise [abstract]. Mid-Atlantic ACSM: 1992; Winchester (MD)

  69. Deschenes MR, Kraemer WJ, Maresh CM, et al. Exercise-induced hormonal changes and their effects upon skeletal muscle tissue. Sports Med 1991; 12(2): 80–93

    PubMed  CAS  Google Scholar 

  70. Thuma JR, Gilders R, Verdun M, et al. Circadian rhythm of cortisol confounds cortisol responses to exercise: implications for future research. J Appl Physiol 1995; 78(5): 1657–64

    PubMed  CAS  Google Scholar 

  71. Wilson JD, Griffin JE. The use and misuse of androgens. Metabolism 1980; 29: 1278–95

    PubMed  CAS  Google Scholar 

  72. Burgos MH, Vitale-Calpe R, Aoki A. Fine structure of the testis and its functional significance. In: Johnson AD, Gomes WR, Vandemark NL, editors. The testis. New York: Academic Press, 1970: 551–649

    Google Scholar 

  73. Lipsett M. Steroid hormones. In: Yen SSC, Jaffe RB, editors. Reproductive endocrinology: physiology, pathophysiology and clinical management. Philadelphia: W.B. Saunders, 1986; 140–153

    Google Scholar 

  74. Griffin JE, Wilson JD. Disorder of the testes and the male reproductive tract. In: Wilson JD, Foster DW, editors. Williams textbook of endocrinology, 8th ed. Philadelphia: W.B. Saunders, 1992: 799–852

    Google Scholar 

  75. Florini JR. Hormonal control of muscle cell growth. J Anim Sci 1985; 61: 21–37

    Google Scholar 

  76. Silverman AJ, Krey LC, Zimmerman EA. A comparative study of the luteinizing hormone releasing hormone (LHRH) neuronal networks in mammals. Biol Reprod 1979; 20: 98–110

    PubMed  CAS  Google Scholar 

  77. Dufau ML, Catt KJ. Gonadotropin receptors and regulation of steroidogenesis in the testis and ovary. Vitam Horm 1978; 36: 461–592

    PubMed  CAS  Google Scholar 

  78. Robaire B, Bayly SF. Testicular signaling: Incoming and outgoing messages. Ann NY Acad Sci 1989; 564: 250–60

    PubMed  CAS  Google Scholar 

  79. Häkkinen K, Pakarinen A, Alén M, et al. Serum hormones during prolonged training of neuromuscular performance. Eur J Appl Physiol 1985; 53: 287–93

    Google Scholar 

  80. Cumming DC, Wheeler GD, McColl EM. The effect of exercise on reproductive function in men. Sports Med 1989; 7: 1–17

    PubMed  CAS  Google Scholar 

  81. Häkkinen K, Pakarinen A. Serum hormones in male strength athletes during intensive short-term strength training. Eur J Appl Physiol 1991; 63: 194–9

    Google Scholar 

  82. Staron RS, Karapondo DL, Kraemer WJ, et al. Skeletal muscle adaptations during early phase of heavy-resistance training in men and women. J Appl Physiol 1994; 76(3): 1247–55

    PubMed  CAS  Google Scholar 

  83. Barron JL, Noakes TD, Levy W, et al. Hypothalamic dysfunction in overtrained athletes. J Clin Endocrinol Metab 1985; 60: 803–6

    PubMed  CAS  Google Scholar 

  84. Triplett NT, Kraemer WJ, Fry AC, et al. Hormonal responses to tournament wrestling [abstract]. Med Sci Sports Exerc 1993; 25(5): S171

    Google Scholar 

  85. Fry RW, Morton AR, Garcia-Webb P, et al. Monitoring exercise stress by changes in metabolic and hormonal responses over a 24-h period. Eur J Appl Physiol 1991; 63: 228–34

    CAS  Google Scholar 

  86. Bleisch WV, Harrelson A. Androgens modulate endplate size and ACh receptor density at synapses in rat levator ani muscle. J Neurobiol 1989; 20(4): 189–202

    PubMed  CAS  Google Scholar 

  87. Sanghera MK, Grady S, Smith W, et al. Incertohypothalamic A13 dopamine neurons: effect of gonadal steroids on tyrosine hydroxylase. Neuroendocrinol 1991; 53: 268–75

    CAS  Google Scholar 

  88. Deschenes MR, Maresh CM, Covault JM, et al. Endurance and resistance exercise induce muscle fiber type specific responses in androgen binding. J Steroid Biochem Mol Biol 1994; 50(3–4): 175–9

    PubMed  CAS  Google Scholar 

  89. Vaitukaitis JL, Ross GD, Braunstein GD, et al. Gonadotropins and their subunits: basic and clinical studies. Recent Prog Horm Res 1976; 32: 289–331

    PubMed  CAS  Google Scholar 

  90. Dufau ML, Veldhuis JD, Fraioli F, et al. Mode of secretion of bioactive luteinizing hormone in man. J Endocrinol Metab 1983; 57: 993–1000

    CAS  Google Scholar 

  91. Conn PM, Morrell DV, Dufau ML, et al. Gonadotropin releasing hormone action in cultured pituicytes: independence of luteinizing hormone release and adenosine 3′,5′-monophosphate production. Endocrinology 1979; 104: 448–53

    PubMed  CAS  Google Scholar 

  92. Lacroix A, McKenna TJ, Rabinowitz D. Sex steroid modulation of gonadotropins in normal men and androgen insensitivity syndrome. J Clin Endocrinol Metab 1979; 48: 235–40

    PubMed  CAS  Google Scholar 

  93. Hyatt PJ, Bhatt K, Tait JF. Steroid biosynthesis by zona fasciculata and zona reticularis cells purified from the mammalian adrenal cortex. J Steroid Biochem 1983; 19: 953–9

    PubMed  CAS  Google Scholar 

  94. Orth DN, Kovacs WJ, Debold CR. The adrenal cortex. In: Wilson JD, Foster DW, editors. Williams textbook of endocrinology, 8th Edition. Philadelphia: W.B. Saunders, 1992: 489–619

    Google Scholar 

  95. Rousseau GG, Baxter JD, Higgins SJ. Steroid-induced nuclear binding of glucocorticoid receptors in intact hepatoma cells. J Mol Biol 1973; 79: 539–54

    PubMed  CAS  Google Scholar 

  96. Jones MT, Gillham B. Factors involved in the regulation of adrenocorticotropic hormone/β-lipotropic hormone. Physiol Rev 1988; 68: 743–818

    PubMed  CAS  Google Scholar 

  97. Beyer HS, Matta SG, Sharp BM. Regulation of the messenger ribonucleic acid for corticotropin-releasing factor and vasopressin in the paraventricular nucleus and other brain sites of the rat. Endocrinology 1988; 123: 2117–23

    PubMed  CAS  Google Scholar 

  98. Lundblad JR, Roberts JL. Regulation of proopiomelanocortin gene expression in pituitary. Endocrin Rev 1988; 9: 135–58

    CAS  Google Scholar 

  99. Hall PF. Trophic stimulation of steroidogenesis: in search of the elusive trigger. Recent Prog Horm Res 1985; 41: 1–31

    PubMed  CAS  Google Scholar 

  100. Holzwarth MA, Cunningham LA, Kleitman N. The role of adrenal nerves in the regulation of adrenocortical function. Ann NY Acad Sci 1987; 512: 449–64

    PubMed  CAS  Google Scholar 

  101. Chen YZ, Hua SY, Wang CA, et al. An electrophysiological study on the membrane receptor-mediated action of glucocorticoids in mammalian neurons. Neuroendocrinol 1991; 53 Suppl. 1: 25–30

    CAS  Google Scholar 

  102. Ciranello RD. Regulation of adrenal catecholamine biosynthetic enzymes: integration of neuronal and hormonal stimuli in response to stress. In: Usdin E, Kvetnansky R, Kopin IJ, editors. Catecholamines and stress: recent advances. New York: Elsevier/North Holland, 1980: 317–27

    Google Scholar 

  103. Kalin NH, Dawson GW. Neuroendocrine dysfunction in depression: hypothalamic-anterior pituitary systems. Trends Neurosci 1986; 9: 261–6

    CAS  Google Scholar 

  104. Eipper BA, Mains RE. Structure and biosynthesis of pro-adrenocorticotropin/endorphin and related peptides. Endocr Rev 1980; 1: 1–27

    PubMed  CAS  Google Scholar 

  105. Jackson RV, DeCherney GS, DeBold CR, et al. Synthetic ovine corticotropin-releasing hormone: simultaneous release of proopiomelanocortin peptides in man. J Clin Endocrinol Metab 1984; 58: 740–3

    PubMed  CAS  Google Scholar 

  106. Catalano RD, Stuve L, Ramachandran J. Characterization of corticotropin receptors in human adrenocortical cells. J Clin Endocrinol Metab 1986; 62: 300–4

    PubMed  CAS  Google Scholar 

  107. Gill GN. ACTH regulation of the adrenal cortex. Pharmacol Ther 1976; 2: 313–38

    CAS  Google Scholar 

  108. Farrell PA. Adrenocorticotropic hormone and exercise. In: Fotherby K, Pal SB, editors. Exercise endocrinology. New York: Walter de Grayter, 1985: 139–56

    Google Scholar 

  109. Vale W, Speiss J, Rivier C, et al. Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. Science 1981; 213: 1394–7

    PubMed  CAS  Google Scholar 

  110. Veldhuis JD, Iranmanesh A, Johnson ML, et al. Amplitude, but not frequency, modulation of adrenocorticotropin secretory bursts gives rise to the myctohemeral rhythm of the corticotropic axis in man. J Clin Endocrinol Metab 1990; 71: 452–63

    PubMed  CAS  Google Scholar 

  111. Vlahos CJ, Matter WF. Signal transduction in neutrophil activation phosphatidylinositol 3-kinase is stimulated without tyrosine phosphorylation. FEBS 1992; 309: 242–8

    CAS  Google Scholar 

  112. Weitzman ED, Fukushima DK, Nogeire C, et al. Twenty-four hour pattern of the episodic secretion of cortisol in normal subjects. J Clin Endocrinol Metab 1971; 33: 14–22

    PubMed  CAS  Google Scholar 

  113. Rivier C, Brownstein M, Speiss J, et al. In vivo corticotropin-releasing factor-induced secretion of adrenocorticotropin, β-endorphin and corticosterone. Endocrinology 1982; 110: 272–8

    PubMed  CAS  Google Scholar 

  114. Millan MA, Abou-Samra AB, Wynn PC, et al. Receptors and action of corticotropin-releasing hormone in the primate pituitary gland. J Clin Endocrinol Metab 1987; 64: 1036–41

    PubMed  CAS  Google Scholar 

  115. Giguere V, Labrie F, Côte J, et al. Stimulation of cyclic AMP accumulation and corticotropin release by ovine corticotropin-releasing factor in rat anterior pituitary cells: site of glucocorticoid action. Proc Natl Acad Sci USA 1982; 79: 3466–9

    PubMed  CAS  Google Scholar 

  116. Al-Damluji S. Adrenergic mechanisms in the control of corticotropin secretion J Endocrinol 1988; 119: 5–14

    CAS  Google Scholar 

  117. Kjaer M, Secher NH, Bach FW, et al. Role of motor center activity for hormonal changes and substrate mobilization in humans. Am J Physiol 1987; 253: R687–95

    PubMed  CAS  Google Scholar 

  118. Häkkinen K, Pakarinen A. Acute hormonal responses to two different fatiguing heavy-resistance protocols in male athletes. J Appl Physiol 1993; 74(2): 882–7

    PubMed  Google Scholar 

  119. Koziris LP, Fry AC, Kraemer WJ, et al. Hormonal and competitive performance responses to an overreaching training stimulus in elite junior weightlifters [abstract]. J Appl Sport Sci Res 1992; 6(3): 186

    Google Scholar 

  120. Vervoorn C, Quist AM, Vermulst LJM, et al. The behavior of plasma free testosterone/cortisol ratio during a season of elite rowing training. Int J Sports Med 1991; 12(3): 257–63

    PubMed  CAS  Google Scholar 

  121. Thorner MO, Vance ML, Horvath E, et al. The anterior pituitary. In: Wilson JD, Foster DW, editors. Williams textbook of endocrinology, 8th Edition. Philadelphia: W.B. Saunders, 1992: 221–310

    Google Scholar 

  122. Lewis UL. Growth hormone: what is it and what does it do? TEM 1992; 3(4): 117–21

    PubMed  CAS  Google Scholar 

  123. Luthman MI, Jonsdottir B, Skoog IL, et al. Monoclonal antibodies reveal circulating GH of higher molecular weight not detectable by conventional assays. Acta Endocrinol 1990; 123: 317–25

    PubMed  CAS  Google Scholar 

  124. Salmon Jr WD, Daughaday WH. A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro. J Lab Clin Med 1957; 49: 825

    PubMed  CAS  Google Scholar 

  125. Kostyo JL, Hotchkiss J, Knobil E. Stimulation of amino acid transport in isolated diaphragm by growth hormone added in vitro. Science 1959; 130: 1653–4

    PubMed  CAS  Google Scholar 

  126. Atkison PR, Weidman ER, Baumhick B. Release of somatomedin-like activity by cultured WI-38 human fibroblasts. Endocrinol 1980; 106: 2006–12

    CAS  Google Scholar 

  127. Van Helder WP, Radomski MW, Goode RC. Growth hormone responses during intermittent weight lifting exercise in men. Eur J Appl Physiol 1984; 53: 31–4

    Google Scholar 

  128. Lukaszewska J, Biczowa B, Bobilewicz D, et al. Effect of physical exercise on plasma cortisol and growth hormone levels in young weight lifters. Endokrynol Pol 1976; 27(2): 149–57

    PubMed  CAS  Google Scholar 

  129. Skierska E, Ustupska J, Biczowa B, et al. Effect of physical exercise on plasma cortisol, testosterone and growth hormone levels in weight lifters. Endokrynol Pol 1976; 27(2): 159–65

    PubMed  CAS  Google Scholar 

  130. Landsberg L, Young JB. Catecholamines and the adrenal medulla. In: Wilson JD, Foster DW, editors. Williams textbook of endocrinology, 8th Ed. Philadelphia: W.B. Saunders, 1992: 621–705

    Google Scholar 

  131. Ashkar E, Stevens JJ, Houssay B. Role of the sympathico-adrenal system in the hemodynamic response to exercise in dogs. Am J Physiol 1968; 214: 22–7

    PubMed  CAS  Google Scholar 

  132. Ruffolo RR. Spare alpha adrenoceptors in the peripheral circulation: excitation-contraction coupling. Fed Proc 1986; 45: 2341–6

    PubMed  CAS  Google Scholar 

  133. Tomita T. Actions of catecholamines on skeletal muscle. In: Greep RO, Astwood EB, editors. Handbook of physiology. Sect. 7: Endocrinology, vol. VI. Washington, DC: American Physiological Society, 1975: 537–52

    Google Scholar 

  134. Richter EA, Ruderman NB, Galbo H. Alpha and beta adrenergic effects on metabolism in contracting, perfused muscle. Acta Physiol Scand 1982; 116: 215–22

    PubMed  CAS  Google Scholar 

  135. Häkkinen K, Pakarinen A, Alén M, et al. Neuromuscular and hormonal responses in elite athletes to two successive strength training sessions in one day. Eur J Appl Physiol 1988; 57: 133–9

    Google Scholar 

  136. Richter EA, Ruderman NB, Gavros H, et al. Muscle glycogenolysis during exercise: dual control by epinephrine and contractions. Am J Physiol 1982; 242 (Endocrinol Metab 5): E25–E32

    PubMed  CAS  Google Scholar 

  137. Heinsimer JA, Lefkowitz RJ. Adrenergic receptors: biochemistry, regulation, molecular mechanism, and clinical implications. J Lab Clin Med 1982; 100: 641–58

    PubMed  CAS  Google Scholar 

  138. Coupland RE. The chromaffin system. In: Blaschko H, Muscholl E, editors. Catecholamines: handbook of experimental pharmacology, Vol. 33. Berlin: Springer-Verlag, 1972; 16–39

    Google Scholar 

  139. Perlman RL, Chalfie M. Catecholamine release from the adrenal medulla. Clin Endocrinol Metab 1977; 6: 551–76

    PubMed  CAS  Google Scholar 

  140. Perlman RL, Role LW. The coordinate control of catecholamine secretion, synthesis and reuptake in chromaffin cells. In: Ben-Jonathan N, Bahr JM, RI Weiner, editors. Catecholamines as hormone regulators. New York: Raven Press, 1985: 215–21

    Google Scholar 

  141. Ciranello RD. Regulation of phenylethanolamine-N-methyl-transferase In: Usdin E, Snyder S, editors. Frontiers in catecholamine research. New York: Pergamon 1973: 101–5

    Google Scholar 

  142. Nesher R, Karl IE, Kipnis DM. Epitrochlearis muscle, II. Metabolic effects of contraction and catecholamines. Am J Physiol 1980; 239 (Endocrinol Metab 2): E461–7

    PubMed  CAS  Google Scholar 

  143. Holmberg E, Waldeck B. On the possible role of potassium ions in the action of terbutaline on skeletal muscle contractions. Acta Pharmacol et Toxicol 1980; 46: 141–9

    CAS  Google Scholar 

  144. Fellenius E, Hedberg R, Holmberg E, et al. Functional and metabolic effects of terbutaline and propranolol in fast- and slow-contracting skeletal muscle. Acta Physiol Scand 1980; 109: 89–95

    PubMed  CAS  Google Scholar 

  145. Clausen T, Flatman JA. β2-Adrenoceptors mediate the stimulating effect of adrenaline on active electrogenic Na-K-transport in rat soleus muscle. Br J Pharmac 1980; 68: 749–55

    CAS  Google Scholar 

  146. Carlson E, Fellenius E, Lundborg P, et al. β-Adrenoceptor blockers, plasma-potassium, and exercise. Lancet 1978; II: 424–5

    Google Scholar 

  147. Issekutz B. Role of beta-adrenergic receptors in mobilization of energy sources in exercising dogs. J Appl Physiol 1978; 44: 869–76

    PubMed  Google Scholar 

  148. Clar MG, Patten GS. Adrenaline activation of phosphofructokinase in rat heart mediated by alpha-receptor mechanism independent of cyclic AMP. Nature 1981; 292: 461–3

    Google Scholar 

  149. Hirano T, Kobayashi S. A functional heterogeneity in chromaffin cells of the mouse adrenal medulla. In: Izumi F, Oka M, Kumakura K, editors. Synthesis, storage and secretion of adrenal catecholamines. Oxford: Pergamon Press, 1982: 127–33

    Google Scholar 

  150. Kinderman W, Schnabel A, Schmitt WM, et al. Catecholamines, growth hormone, cortisol, insulin and sex hormones in anaerobic and aerobic exercise. Eur J Appl Physiol 1982; 49: 389–99

    Google Scholar 

  151. Jezova D, Vigas M, Tatar P, et al. Plasma testosterone and catecholamine responses to physical exercise of different intensities in men. Eur J Appl Physiol 1985; 54: 62–6

    CAS  Google Scholar 

  152. Lehmann M, Keul J. Free plasma catecholamines, heart rates, lactate levels, and oxygen uptake in competition weight lifters, cyclists, and untrained control subjects. Int J Sports Med 1986; 7(1): 18–21

    PubMed  CAS  Google Scholar 

  153. Stone MH, Fry AC, Kraemer WJ, et al. Physiological responses to short term overreaching in weightlifting: a report to the U.S. Weightlifting Federation Board of Directors. Colorado Springs: U.S. Weightlifting Federation, 1993

    Google Scholar 

  154. Péronnet F, Thibault G, Perrault H, et al. Sympathetic response to maximal bicycle exercise before and after leg strength training. Eur J Appl Physiol 1986; 55: 1–4

    Google Scholar 

  155. Jost J, Weiss M, Weicker H. Comparison of sympatho-adrenergic regulation at rest and of the adrenoceptor system in swimmers, long-distance runners, weight lifters, wrestlers, and untrained men. Eur J Appl Physiol 1989; 58: 596–604

    CAS  Google Scholar 

  156. Eik-nes KB. An effect of isoproterenol on rates of synthesis and secretion of testosterone. Am J Physiol 1969; 217(6): 1764–70

    PubMed  CAS  Google Scholar 

  157. Jezova D, Vigas M. Testosterone response to exercise during blockade and stimulation of adrenergic receptors in man. Hormone Res 1981; 15: 141–7

    PubMed  CAS  Google Scholar 

  158. Brown MJ, Jenner DA, Allison DJ, et al. Variations in individual organ release of noradrenaline measured by an improved radioenzymatic technique: limitations of peripheral venous measurements in the assessment of sympathetic nervous activity. Clin Sci 1981; 61: 585–90

    PubMed  CAS  Google Scholar 

  159. Kopin IJ. Catecholamine metabolism (and the biochemical assessment of sympathetic activity). Clin Endocrinol Metab 1977; 6: 525–49

    PubMed  CAS  Google Scholar 

  160. Tipton KF. Biochemical aspects of monoamine oxidase. Br Med Bull 1973; 29: 116–9

    CAS  Google Scholar 

  161. Iverson LL. Catecholamine uptake process. Br Med Bull 1973; 29: 130–5

    Google Scholar 

  162. Hjemdahl P. Measurements of plasma catecholamines by HPLC and the relation of their concentrations to sympathoadrenal activity. In: Joseph MH, Fillenz M, Macdonald IM, editors. Monitoring neurotransmitter release during behaviour. Chichester: Ellis Horwood, 1986: 17–32

    Google Scholar 

  163. Wallin BG, Sundlof G, Eriksson B-M, et al. Plasma noradrenaline correlates to sympathetic muscle nerve activity in normotensive man. Acta Physiol Scand 1981; 111: 69–73

    PubMed  CAS  Google Scholar 

  164. Smith AD, Winkler H. Fundamental mechanisms in the release of catecholamines. In: Blaschko H, Muscholl E, editors. Catecholamines, Handbook of experimental pharmacology, Vol. 33. Berlin: Springer-Verlag, 1972: 538–617

    Google Scholar 

  165. Guezennec Y, Leger L, Lhoste F, et al. Hormone and metabolite response to weight-lifting training sessions. Int J Sports Med 1986; 7: 100–5

    PubMed  CAS  Google Scholar 

  166. Kilpatrick DL, Lewis RV, Stein S, et al. Release of enkephalins and enkephalin-containing polypeptides from perfused beef adrenal glands. Proc Natl Acad Sci USA 1980; 77: 7473–5

    PubMed  CAS  Google Scholar 

  167. Livett AR, Dean DM, Whelan LG, et al. Co-release of enkephalin and catecholamines from cultured adrenal chromaffin cells. Nature 1981; 289: 317–9

    PubMed  CAS  Google Scholar 

  168. Udenfriend S, Kilpatrick DL. Proenkephalin and the products of its processing: chemistry and biology. In: The peptides, Vol. 6. Orlando (FL): Academic Press, 1984: 25–68

    Google Scholar 

  169. Hiddinga HJ, Isaak DD, Lewis RV. Enkephalin-containing peptides processed from the proenkephalin significantly enhances the antibody-forming cell responses to antigens. J Immun 1994; 152: 3748–59

    PubMed  CAS  Google Scholar 

  170. Lett E, Gangloff S, Zimmerman M, et al. Immunogenicity of polysaccharides conjugated to peptides containing T- and B-cell epitopes. Infect Immun 1994; 62: 785–92

    PubMed  CAS  Google Scholar 

  171. Kraemer WJ, Noble B, Culver B, et al. Changes in plasma proenkephalin peptide F and catecholamine levels during graded exercise in men. Proc Natl Acad Sci USA 1985; 82: 6349–51

    PubMed  CAS  Google Scholar 

  172. Katzenstein GE, Lund D, Schultz P, et al. Target tissue distribution of the proenkephalin peptides F, E, and B. Biochem Biophys Res Commun 1987; 146: 184–90

    Google Scholar 

  173. Ebbeling CB, Clarkson PM. Exercise-induced muscle damage and adaptation. Sports Med 1989; 7(4): 207–34

    PubMed  CAS  Google Scholar 

  174. Kraemer WJ, Dziados JE, Marchitelli LJ, et al. Effects of different heavy-resistance exercise protocols on plasma β-endorphin concentrations. J Appl Physiol 1993; 74(1): 450–9

    PubMed  CAS  Google Scholar 

  175. Asmussen E, Klausen K, Nielsen LE, et al. Lactate production and anaerobic work capacity after prolonged exercise. Acta Physiol Scand 1966; 50: 731–42

    Google Scholar 

  176. Stone ME, Keith RE, Marple D, et al. Heart rate and lactate levels during weight-training exercise in trained and untrained men. Phys Sportsmed 1987; 15: 97–105

    Google Scholar 

  177. Tannen RL. Ammonia metabolism. Am J Physiol 1978; 235(4): F265–77

    PubMed  CAS  Google Scholar 

  178. Lowenstein JM. Ammonia production in muscle: the purine nucleotide cycle. Physiol Rev 1972; 52(2): 382–414

    CAS  Google Scholar 

  179. Banister EW, Rajendra W, Mutch BJC. Ammonia as an indicator of exercise stress: implications of recent findings to sports medicine. Sports Med 1985; 2(1): 34–46

    PubMed  CAS  Google Scholar 

  180. Stone MH, Keith RE, Marple D, et al. Physiological adaptations during a one-week junior elite weightlifting camp. Conference Abstracts, Southeastern American College of Sports Medicine; 1989

  181. Warren BJ, Stone MH, Kearney JT, et al. The effects of short-term overwork on performance measures and blood metabolites in elite junior weightlifters. Int J Sports Med 1992; 13: 372–6

    PubMed  CAS  Google Scholar 

  182. Stone MH, O’Bryant H, Garhammer J. A hypothetical model for strength training. J Sports Med Phys Fit 1981; 21: 342–51

    CAS  Google Scholar 

  183. Fry RW, Morton AR, Keast D. Periodisation and the prevention of overtraining. Can J Sport Sci 1992; 17: 241–8

    PubMed  CAS  Google Scholar 

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Fry, A.C., Kraemer, W.J. Resistance Exercise Overtraining and Overreaching. Sports Medicine 23, 106–129 (1997). https://doi.org/10.2165/00007256-199723020-00004

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