Wound healing: the role of growth factors

Anna T Grazul-Bilska; Mary Lynn Johnson; Jerzy J Bilski; Dale A Redmer; Lawrence P Reynolds; Ahmed Abdullah; Kay M Abdullah

doi:10.1358/dot.2003.39.10.799472

Wound healing: the role of growth factors

Drugs Today (Barc). 2003 Oct;39(10):787-800. doi: 10.1358/dot.2003.39.10.799472.

Authors

Anna T Grazul-Bilska¹, Mary Lynn Johnson, Jerzy J Bilski, Dale A Redmer, Lawrence P Reynolds, Ahmed Abdullah, Kay M Abdullah

Affiliation

¹ Department of Animal and Range Sciences and Cell Biology Center, North Dakota State University, Fargo, North Dakota 58105, USA. Anna.Grazul-Bilska@ndsu.nodak.edu

PMID: 14668934
DOI: 10.1358/dot.2003.39.10.799472

Abstract

Wound healing is a complex biological process that requires cellular interactions between a variety of cells, including fibroblasts, myofibroblasts, smooth muscle cells, endothelial cells, keratinocytes and immune cells. These interactions are mediated by numerous factors such as growth factors, hormones, blood components and second messengers. Several growth factors that are released at the wound site are presumed to be necessary for wound healing. These include epidermal growth factor (EGF), fibroblast growth factor (FGF), insulin-like growth factor (IGF), keratinocyte growth factor (KGF), platelet-derived growth factor (PDGF), transforming growth factor (TGF) and vascular endothelial growth factor (VEGF). The clinical use of growth factors to stimulate the healing of wounds is currently being investigated. Several growth factors, including PDGF, FGF-2, IGF and KGF, have been used in clinical trials, and PDGF is currently approved for use in human medicine.

Publication types

Review

MeSH terms

Animals
Clinical Trials as Topic
Epidermal Growth Factor / physiology
Epidermal Growth Factor / therapeutic use
Fibroblast Growth Factors / physiology
Fibroblast Growth Factors / therapeutic use
Growth Substances / physiology*
Growth Substances / therapeutic use
Humans
Insulin-Like Growth Factor I / physiology
Insulin-Like Growth Factor I / therapeutic use
Insulin-Like Growth Factor II / physiology
Insulin-Like Growth Factor II / therapeutic use
Platelet-Derived Growth Factor / physiology
Platelet-Derived Growth Factor / therapeutic use
Transforming Growth Factor beta / physiology
Transforming Growth Factor beta / therapeutic use
Vascular Endothelial Growth Factor A / physiology
Vascular Endothelial Growth Factor A / therapeutic use
Wound Healing / drug effects
Wound Healing / physiology*

Substances

Growth Substances
Platelet-Derived Growth Factor
Transforming Growth Factor beta
Vascular Endothelial Growth Factor A
Fibroblast Growth Factors
Epidermal Growth Factor
Insulin-Like Growth Factor I
Insulin-Like Growth Factor II