The purpose of this study was to examine the responses of peak torque (PT), mean power output (MP), mechanomyographic (MMG) and electromyographic (EMG) amplitude and mean power frequency (MPF) of the vastus lateralis (VL), rectus femoris (RF), and vastus medialis (VM) in males and females during maximal, concentric isokinetic muscle actions. Subjects performed maximal leg extensions at 60 degrees s(-1), 120 degrees s(-1), 180 degrees s(-1), 240 degrees s(-1), 300 degrees s(-1), 360 degrees s(-1), 420 degrees s(-1), and 480 degrees s(-1). No gender differences were observed, but there were muscle-specific differences for the patterns of MMG MPF, EMG amplitude, and EMG MPF. The MP and MMG amplitude increased to 180-240 degrees s(-1), plateaued, and then decreased to 480 degrees s(-1). MMG MPF for the VL and VM remained unchanged to 300 degrees s(-1), but then increased to 480 degrees s(-1). The EMG amplitude for the RF and EMG MPF for the VL decreased across velocity. Overall, these findings indicated that there were muscle-specific, velocity-related differences in the associations among motor control strategies (EMG amplitude and MPF) and the mechanical aspects of isokinetic muscular activity (MMG amplitude and MPF).