Multiple triggers for hyperthermic fatigue and exhaustion

Exerc Sport Sci Rev. 2004 Jul;32(3):100-6. doi: 10.1097/00003677-200407000-00005.

Abstract

It has been proposed that a critical body temperature exists at which muscle activation is impaired through a direct effect of high brain temperature decreasing the central drive to exercise, but other factors may also inhibit performance in the heat. An integrative physiological model is presented to stimulate research into mechanisms of hyperthermic fatigue and exhaustion.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Body Temperature / physiology
  • Brain / blood supply
  • Brain / metabolism
  • Brain / physiopathology
  • Cytokines / metabolism
  • Exercise / physiology*
  • Fever / metabolism
  • Fever / physiopathology*
  • Heat Exhaustion / metabolism
  • Heat Exhaustion / physiopathology*
  • Humans
  • Models, Biological
  • Muscle Fatigue / physiology*
  • Regional Blood Flow / physiology

Substances

  • Cytokines