Effects of glucocorticoids on the hypothalamic-pituitary-adrenal axis in children and adults

Tanya Gulliver; Nemr Eid

doi:10.1016/j.iac.2005.04.001

Effects of glucocorticoids on the hypothalamic-pituitary-adrenal axis in children and adults

Immunol Allergy Clin North Am. 2005 Aug;25(3):541-55, vii. doi: 10.1016/j.iac.2005.04.001.

Authors

Tanya Gulliver¹, Nemr Eid

Affiliation

¹ Department of Pediatrics, University of Louisville School of Medicine, 571 South Floyd Street, Louisville, KY 40202, USA.

PMID: 16054542
DOI: 10.1016/j.iac.2005.04.001

Abstract

Inhaled and intranasal corticosteroids are widely used as effective, first-line treatments for asthma and allergic rhinitis. Despite a good safety profile of these formulations, there is increasing concern about their propensity to produce systemic adverse effects. Suppression of the hypothalamic-pituitary-adrenal axis is one of the most important potential complications. This article reviews the effects of inhaled and intranasal corticosteroids on the hypothalamic-pituitary-adrenal axis function in adults and children.

Publication types

Comparative Study
Review

MeSH terms

Administration, Inhalation
Administration, Intranasal
Adult
Anti-Inflammatory Agents / administration & dosage
Anti-Inflammatory Agents / adverse effects*
Anti-Inflammatory Agents / pharmacokinetics
Asthma / drug therapy
Child
Glucocorticoids / administration & dosage
Glucocorticoids / adverse effects*
Glucocorticoids / pharmacokinetics
Humans
Hypothalamo-Hypophyseal System / drug effects*
Nasal Polyps / drug therapy
Nebulizers and Vaporizers
Pituitary-Adrenal System / drug effects*
Rhinitis / drug therapy

Substances

Anti-Inflammatory Agents
Glucocorticoids