Abstract
Exercise leads to changes in muscle phenotype with important implications for exercise performance and health. A recent paper in Cell by Narkar et al. (2008) shows that many of the adaptations in muscle phenotype elicited by exercise can be mimicked by genetic manipulation and drug treatment in mice.
MeSH terms
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AMP-Activated Protein Kinases
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Adaptation, Physiological / physiology*
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Aminoimidazole Carboxamide / analogs & derivatives
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Aminoimidazole Carboxamide / pharmacology
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Aminoimidazole Carboxamide / therapeutic use
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Animals
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Energy Metabolism / drug effects
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Energy Metabolism / genetics*
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Mice
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Multienzyme Complexes / drug effects
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Multienzyme Complexes / metabolism
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Muscle Fibers, Skeletal / drug effects
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Muscle Fibers, Skeletal / metabolism*
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Muscle Fibers, Skeletal / ultrastructure
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Muscle, Skeletal / drug effects
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Muscle, Skeletal / metabolism*
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Oxygen Consumption / drug effects
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Oxygen Consumption / genetics
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Peroxisome Proliferator-Activated Receptors / drug effects
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Peroxisome Proliferator-Activated Receptors / metabolism
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Physical Conditioning, Animal / physiology*
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Protein Serine-Threonine Kinases / drug effects
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Protein Serine-Threonine Kinases / metabolism
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Ribonucleotides / pharmacology
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Ribonucleotides / therapeutic use
Substances
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Multienzyme Complexes
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Peroxisome Proliferator-Activated Receptors
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Ribonucleotides
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Aminoimidazole Carboxamide
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Protein Serine-Threonine Kinases
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AMP-Activated Protein Kinases
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AICA ribonucleotide