The concordance correlation coefficient for repeated measures estimated by variance components

J Biopharm Stat. 2009;19(1):90-105. doi: 10.1080/10543400802527890.

Abstract

The concordance correlation coefficient (CCC) is an index that is commonly used to assess the degree of agreement between observers on measuring a continuous characteristic. Here, a CCC for longitudinal repeated measurements is developed through the appropriate specification of the intraclass correlation coefficient from a variance components linear mixed model. A case example and the results of a simulation study are provided.

MeSH terms

  • Algorithms
  • Analysis of Variance
  • Area Under Curve
  • Computer Simulation
  • Confidence Intervals
  • Humans
  • Hydrocortisone / blood
  • Linear Models
  • Models, Statistical*
  • Observer Variation*
  • Pharmaceutical Preparations / administration & dosage
  • Pharmaceutical Preparations / blood
  • Pharmaceutical Preparations / metabolism
  • Pharmacokinetics

Substances

  • Pharmaceutical Preparations
  • Hydrocortisone