The aim of this study is to assess the effect of a 12 week multicomponent exercise training program on the quality of life in females with knee osteoarthritis. Thirty four subjects, aged 50-69 years, completed a 12 week multicomponent exercise training program. The SF-36 and WOMAC were applied at baseline, at mid-training, and post-training, and the responses of the exercise group (EG) and the control group (CG) were compared. The multicomponent training program resulted in significant group differences in all domains of SF-36 (p < 0.004), while there were no group difference in WOMAC domains (p > 0.004). In the EG between mid-training and baseline period vitality score increased; physical performance and general health scores increased between mid-training and post-training period; physical function, body pain, mental health, vitality, and general health scores increased between baseline and post-training period (p < 0.004). Between mid-training and baseline period of the WOMAC domains changed in the EG (p > 0.004), while all domains increased between mid-training and post-training and also between baseline and post-training (p < 0.004). Changes in quality of life after multicomponent training are affected by the different evaluation techniques.