How does the vertebrate embryo make a nervous system? This complex question has been
at the center of developmental biology for many years. The earliest step in this process–the …

Human embryonic stem cells (hESCs) self-renew indefinitely and give rise to derivatives of
all three primary germ layers, yet little is known about the signaling cascades that govern …

A major task of the central nervous system (CNS) is to control behavioral actions, which
necessitates a precise regulation of muscle activity. The final components of the circuitry …

Single-cell RNA sequencing data can unveil the molecular diversity of cell types. Cell type
atlases of the mouse spinal cord have been published in recent years but have not been …

Differential expression analysis in single-cell transcriptomics enables the dissection of cell-
type-specific responses to perturbations such as disease, trauma, or experimental …

To understand the cellular basis of behavior, it is necessary to know the cell types that exist
in the nervous system and their contributions to function. Spinal networks are essential for …

The mammalian spinal cord functions as a community of cell types for sensory processing,
autonomic control, and movement. While animal models have advanced our understanding …

The rich behavioral repertoire of animals is encoded in the CNS as a set of motorneuron
activation patterns, also called'motor synergies'. However, the neurons that orchestrate …

The TGFβ superfamily of ligands plays key functions in development and disease. In both
human and mouse embryonic stem cells, a member of this family, GDF3, is specifically …

After spinal cord injury, tissue distal to the lesion contains undamaged cells that could
support or augment recovery. Targeting these cells requires a clearer understanding of their …