User profiles for "author:C Thomas Appleton"

C. Thomas Appleton

Western University, Canada
Verified email at uwo.ca
Cited by 1898

Are we missing the target? Are we aiming too low? What are the aerobic exercise prescriptions and their effects on markers of cardiovascular health and systemic …

JM Schulz, TB Birmingham, HF Atkinson… - British journal of sports …, 2020 - bjsm.bmj.com
Objectives We systemically reviewed published studies that evaluated aerobic exercise
interventions in patients with knee osteoarthritis (OA) to:(1) report the frequency, intensity …

A scoping review of how early-stage knee osteoarthritis has been defined

JW Liew, LK King, A Mahmoudian, Q Wang… - Osteoarthritis and …, 2023 - Elsevier
Background Early-stage knee osteoarthritis (KOA) classification criteria will enable
consistent identification and trial recruitment of individuals with knee OA at an earlier stage …

ADAMTS-7 forms a positive feedback loop with TNF-α in the pathogenesis of osteoarthritis

Y Lai, X Bai, Y Zhao, Q Tian, B Liu, EA Lin… - Annals of the …, 2014 - ard.bmj.com
Objective To examine the expression of ADAMTS-7 during the progression of osteoarthritis
(OA), defining its role in the pathogenesis of OA, and elucidating the molecular events …

Impaired efferocytosis by synovial macrophages in patients with knee osteoarthritis

L Del Sordo, GB Blackler, HT Philpott… - Arthritis & …, 2023 - Wiley Online Library
Objective Osteoarthritis (OA) exposes all joint tissues to physiologic stresses, increasing the
need to clear apoptotic cells from tissues, including the synovium. We undertook this study to …

Polymer particles for the intra-articular delivery of drugs to treat osteoarthritis

X Mei, IJ Villamagna, T Nguyen, F Beier… - Biomedical …, 2021 - iopscience.iop.org
Osteoarthritis (OA) is a leading cause of chronic disability. It is a progressive disease,
involving pathological changes to the entire joint, resulting in joint pain, stiffness, swelling …

[HTML][HTML] Tensile strain and altered synovial tissue metabolism in human knee osteoarthritis

HT Philpott, TB Birmingham, B Fiset, LA Walsh… - Scientific Reports, 2022 - nature.com
Synovium is critical for maintaining joint homeostasis and may contribute to
mechanobiological responses during joint movement. We investigated mechanobiological …

[HTML][HTML] Human osteoarthritis knee joint synovial fluids cleave and activate Proteinase-Activated Receptor (PAR) mediated signaling

A Chandrabalan, A Firth, RB Litchfield, CT Appleton… - Scientific Reports, 2023 - nature.com
Osteoarthritis (OA) is the most prevalent joint disorder with increasing worldwide incidence.
Mechanistic insights into OA pathophysiology are evolving and there are currently no …

Synovitis is associated with constant pain in knee osteoarthritis: a cross-sectional study of OMERACT knee ultrasound scores

HT Philpott, TB Birmingham, R Pinto… - The Journal of …, 2022 - jrheum.org
Objective To examine the association between ultrasound (US)-detected knee inflammation
and intermittent and constant pain experiences in patients with knee osteoarthritis (OA) …

[HTML][HTML] Sex-differences and associations between complement activation and synovial vascularization in patients with late-stage knee osteoarthritis

EU Sodhi, HT Philpott, MKM Carter… - Frontiers in …, 2022 - frontiersin.org
Purpose Synovial inflammation in knee osteoarthritis (OA) causes disorganized synovial
angiogenesis and complement activation in synovial fluid, but links between complement …

Changes and associations between gait biomechanics and knee inflammation after aspiration and glucocorticoid injection for knee osteoarthritis

RF Pinto, TB Birmingham, HT Philpott… - Arthritis Care & …, 2023 - Wiley Online Library
Objective Although knee inflammation is thought to adversely affect joint function in patients
with knee osteoarthritis (OA), the effects of reducing knee inflammation on gait biomechanics …