User profiles for "author:C Thomas Appleton"
C. Thomas AppletonWestern University, Canada Verified email at uwo.ca Cited by 1898 |
Are we missing the target? Are we aiming too low? What are the aerobic exercise prescriptions and their effects on markers of cardiovascular health and systemic …
Objectives We systemically reviewed published studies that evaluated aerobic exercise
interventions in patients with knee osteoarthritis (OA) to:(1) report the frequency, intensity …
interventions in patients with knee osteoarthritis (OA) to:(1) report the frequency, intensity …
A scoping review of how early-stage knee osteoarthritis has been defined
JW Liew, LK King, A Mahmoudian, Q Wang… - Osteoarthritis and …, 2023 - Elsevier
Background Early-stage knee osteoarthritis (KOA) classification criteria will enable
consistent identification and trial recruitment of individuals with knee OA at an earlier stage …
consistent identification and trial recruitment of individuals with knee OA at an earlier stage …
ADAMTS-7 forms a positive feedback loop with TNF-α in the pathogenesis of osteoarthritis
Y Lai, X Bai, Y Zhao, Q Tian, B Liu, EA Lin… - Annals of the …, 2014 - ard.bmj.com
Objective To examine the expression of ADAMTS-7 during the progression of osteoarthritis
(OA), defining its role in the pathogenesis of OA, and elucidating the molecular events …
(OA), defining its role in the pathogenesis of OA, and elucidating the molecular events …
Impaired efferocytosis by synovial macrophages in patients with knee osteoarthritis
L Del Sordo, GB Blackler, HT Philpott… - Arthritis & …, 2023 - Wiley Online Library
Objective Osteoarthritis (OA) exposes all joint tissues to physiologic stresses, increasing the
need to clear apoptotic cells from tissues, including the synovium. We undertook this study to …
need to clear apoptotic cells from tissues, including the synovium. We undertook this study to …
Polymer particles for the intra-articular delivery of drugs to treat osteoarthritis
Osteoarthritis (OA) is a leading cause of chronic disability. It is a progressive disease,
involving pathological changes to the entire joint, resulting in joint pain, stiffness, swelling …
involving pathological changes to the entire joint, resulting in joint pain, stiffness, swelling …
[HTML][HTML] Tensile strain and altered synovial tissue metabolism in human knee osteoarthritis
HT Philpott, TB Birmingham, B Fiset, LA Walsh… - Scientific Reports, 2022 - nature.com
Synovium is critical for maintaining joint homeostasis and may contribute to
mechanobiological responses during joint movement. We investigated mechanobiological …
mechanobiological responses during joint movement. We investigated mechanobiological …
[HTML][HTML] Human osteoarthritis knee joint synovial fluids cleave and activate Proteinase-Activated Receptor (PAR) mediated signaling
A Chandrabalan, A Firth, RB Litchfield, CT Appleton… - Scientific Reports, 2023 - nature.com
Osteoarthritis (OA) is the most prevalent joint disorder with increasing worldwide incidence.
Mechanistic insights into OA pathophysiology are evolving and there are currently no …
Mechanistic insights into OA pathophysiology are evolving and there are currently no …
Synovitis is associated with constant pain in knee osteoarthritis: a cross-sectional study of OMERACT knee ultrasound scores
HT Philpott, TB Birmingham, R Pinto… - The Journal of …, 2022 - jrheum.org
Objective To examine the association between ultrasound (US)-detected knee inflammation
and intermittent and constant pain experiences in patients with knee osteoarthritis (OA) …
and intermittent and constant pain experiences in patients with knee osteoarthritis (OA) …
[HTML][HTML] Sex-differences and associations between complement activation and synovial vascularization in patients with late-stage knee osteoarthritis
EU Sodhi, HT Philpott, MKM Carter… - Frontiers in …, 2022 - frontiersin.org
Purpose Synovial inflammation in knee osteoarthritis (OA) causes disorganized synovial
angiogenesis and complement activation in synovial fluid, but links between complement …
angiogenesis and complement activation in synovial fluid, but links between complement …
Changes and associations between gait biomechanics and knee inflammation after aspiration and glucocorticoid injection for knee osteoarthritis
RF Pinto, TB Birmingham, HT Philpott… - Arthritis Care & …, 2023 - Wiley Online Library
Objective Although knee inflammation is thought to adversely affect joint function in patients
with knee osteoarthritis (OA), the effects of reducing knee inflammation on gait biomechanics …
with knee osteoarthritis (OA), the effects of reducing knee inflammation on gait biomechanics …