Selective pharmacological inhibition of distinct nitric oxide synthase isoforms
GJ Southan, C Szabó - Biochemical pharmacology, 1996 - Elsevier
Nitric oxide (NO) is produced in physiological and pathophysiological conditions by three
distinct isoforms of NO synthase (NOS): endothelial NOS (ecNOS), inducible NOS (iNOS) …
distinct isoforms of NO synthase (NOS): endothelial NOS (ecNOS), inducible NOS (iNOS) …
Poly (ADP-ribose) polymerase inhibitors
GJ Southan, C Szab - Current medicinal chemistry, 2003 - ingentaconnect.com
Poly (ADP-ribose) polymerase-1 (PARP-1) is the principal member of the PARP enzyme
family consisting of PARP-1 and several recently identified novel poly (ADP-ribosyl) ating …
family consisting of PARP-1 and several recently identified novel poly (ADP-ribosyl) ating …
Diabetic endothelial dysfunction: the role of poly (ADP-ribose) polymerase activation
Diabetic patients frequently suffer from retinopathy, nephropathy, neuropathy and
accelerated atherosclerosis. The loss of endothelial function precedes these vascular …
accelerated atherosclerosis. The loss of endothelial function precedes these vascular …
Inosine inhibits inflammatory cytokine production by a posttranscriptional mechanism and protects against endotoxin-induced shock
Extracellular purines, including adenosine and ATP, are potent endogenous
immunomodulatory molecules. Inosine, a degradation product of these purines, can reach …
immunomodulatory molecules. Inosine, a degradation product of these purines, can reach …
Novel phenanthridinone inhibitors of poly (adenosine 5′-diphosphate-ribose) synthetase: potent cytoprotective and antishock agents
P Jagtap, FG Soriano, L Virág, L Liaudet… - Critical care …, 2002 - journals.lww.com
Objective To synthesize novel inhibitors of the nuclear enzyme poly (adenosine 5′-
diphosphate [ADP]-ribose) synthetase (PARS), also known as poly (ADP-ribose) …
diphosphate [ADP]-ribose) synthetase (PARS), also known as poly (ADP-ribose) …
Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide …
C Szabo, GJ Southan… - Proceedings of the …, 1994 - National Acad Sciences
Enhanced formation of nitric oxide (NO) by both the constitutive and the inducible isoforms of
NO synthase (NOS) has been implicated in the pathophysiology of a variety of diseases …
NO synthase (NOS) has been implicated in the pathophysiology of a variety of diseases …
Isothioureas: potent inhibitors of nitric oxide synthases with variable isoform selectivity
GJ Southan, C Szabó… - British journal of …, 1995 - Wiley Online Library
1 The induction of a calcium‐independent isoform of nitric oxide (NO) synthase (iNOS) and a
subsequent enhanced formation of NO has been implicated in the pathophysiology of a …
subsequent enhanced formation of NO has been implicated in the pathophysiology of a …
Poly (ADP-Ribose) polymerase inhibition reduces reperfusion injury after heart transplantation
G Szabó, S Bährle, N Stumpf, K Sonnenberg… - Circulation …, 2002 - Am Heart Assoc
The aim of the present study was to investigate the effects of the novel poly (ADP-ribose)
polymerase (PARP) inhibitor PJ34 (N-(6-oxo-5, 6-dihydro-phenanthridin-2-yl)-N, N …
polymerase (PARP) inhibitor PJ34 (N-(6-oxo-5, 6-dihydro-phenanthridin-2-yl)-N, N …
Localizing antithrombotic and vasodilatory activity with a novel, ultrafast nitric oxide donor
JE Saavedra, GJ Southan, KM Davies… - Journal of medicinal …, 1996 - ACS Publications
Reaction of nitric oxide (NO) with l-proline in methanolic sodium methoxide yields a
diazeniumdiolate product, C5H7N3O4Na2⊙ CH3OH (PROLI/NO), that can be stabilized in …
diazeniumdiolate product, C5H7N3O4Na2⊙ CH3OH (PROLI/NO), that can be stabilized in …
Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase
JG Mabley, P Jagtap, M Perretti, SJ Getting… - Inflammation …, 2001 - Springer
Objective and design: Oxygen-and nitrogen-derived free radicals and oxidants play an
important role in the pathogenesis of various forms of inflammation. Recent work …
important role in the pathogenesis of various forms of inflammation. Recent work …