Background Invasive lobular breast cancer (ILC) is the second most common type of breast
cancer after invasive breast cancer of no special type (NST), representing up to 15% of all …

Immune-checkpoint blockade (ICB) combined with neoadjuvant chemotherapy improves
pathological complete response in breast cancer. To understand why only a subset of …

Objectives To provide an overview of costs associated with the treatment of breast cancer-
related lymphoedema (BCRL) and its possible sequelae, borne by patients or by society …

Since a detailed inventory of endothelial cell (EC) heterogeneity in breast cancer (BC) is
lacking, here we perform single cell RNA-sequencing of 26,515 cells (including 8433 ECs) …

Germline pathogenic alterations in the breast cancer susceptibility genes 1 (BRCA1) and 2
(BRCA2) are the most prevalent causes of hereditary breast and ovarian cancer. The …

Background BRCA1 interacting protein C-terminal helicase 1 (BRIP1) is one of the Fanconi
Anaemia Complementation (FANC) group family of DNA repair proteins. Biallelic mutations …

Genome-wide association studies (GWAS) have identified more than 170 breast cancer
susceptibility loci. Here we hypothesize that some risk-associated variants might act in non …

Objectives Physical inactivity and sedentary behaviour are associated with higher breast
cancer risk in observational studies, but ascribing causality is difficult. Mendelian …

In most mammalian species force of contraction of cardiac muscle increases with increasing
rate of stimulation, ie a positive force‐frequency relationship. In single mouse ventricular …

Questions When added to decongestive lymphatic therapy (DLT), what is the effect of
fluoroscopy-guided manual lymphatic drainage (MLD) versus traditional MLD or placebo …