Natural killer (NK) cells are cytotoxic lymphocytes of the innate immune system that are
capable of killing virally infected and/or cancerous cells. Nearly 20 years ago, NK cell …

Communication between cells is often mediated by secreted signaling molecules that bind
cell surface receptors and modulate the activity of specific intracellular effectors. The Wnt …

Members of the vertebrate Wnt family have been subdivided into two functional classes
according to their biological activities. Some Wnts signal through the canonical Wnt …

Nucleases that cleave unique genomic sequences in living cells can be used for targeted
gene editing and mutagenesis. Here we develop a strategy for generating such reagents …

Permanent modification of the human genome in vivo is impractical owing to the low
frequency of homologous recombination in human cells, a fact that hampers biomedical …

We previously demonstrated that autologous natural killer (NK)–cell therapy after
hematopoietic cell transplantation (HCT) is safe but does not provide an antitumor effect. We …

We developed highly sensitive shuttle vector systems for detection of mutations formed in
human cells using autonomously replicating derivatives of Epstein-Barr virus (EBV). EBV …

Targeted genetic engineering of human pluripotent cells is a prerequisite for exploiting their
full potential. Such genetic manipulations can be achieved using site-specific nucleases …

Genome editing driven by zinc-finger nucleases (ZFNs) yields high gene-modification
efficiencies (> 10%) by introducing a recombinogenic double-strand break into the targeted …

The ubiquity of anthropogenic debris in hundreds of species of wildlife and the toxicity of
chemicals associated with it has begun to raise concerns regarding the presence of …