Discovering the anticancer potential of non-oncology drugs by systematic viability profiling

SM Corsello, RT Nagari, RD Spangler, J Rossen… - Nature cancer, 2020 - nature.com
Anticancer uses of non-oncology drugs have occasionally been found, but such discoveries
have been serendipitous. We sought to create a public resource containing the growth …

Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity

GS Kinker, AC Greenwald, R Tal, Z Orlova, MS Cuoco… - Nature …, 2020 - nature.com
Cultured cell lines are the workhorse of cancer research, but the extent to which they
recapitulate the heterogeneity observed among malignant cells in tumors is unclear. Here …

Peroneal tendon subluxation: the other lateral ankle injury

JA Roth, WC Taylor, J Whalen - British journal of sports medicine, 2010 - bjsm.bmj.com
Ankle injuries are a frequent cause of patient visits to the emergency department and
orthopaedic and primary care offices. Although lateral ligament sprains are the most …

[HTML][HTML] The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity

CK Baumgartner, H Ebrahimi-Nik, A Iracheta-Vellve… - Nature, 2023 - nature.com
Immune checkpoint blockade is effective for some patients with cancer, but most are
refractory to current immunotherapies and new approaches are needed to overcome …

Massively parallel pooled screening reveals genomic determinants of nanoparticle delivery

N Boehnke, JP Straehla, HC Safford, M Kocak… - Science, 2022 - science.org
To accelerate the translation of cancer nanomedicine, we used an integrated genomic
approach to improve our understanding of the cellular processes that govern nanoparticle …

INK4 tumor suppressor proteins mediate resistance to CDK4/6 kinase inhibitors

Q Li, B Jiang, J Guo, H Shao, IS Del Priore, Q Chang… - Cancer discovery, 2022 - AACR
Abstract Cyclin-dependent kinases 4 and 6 (CDK4/6) represent a major therapeutic
vulnerability for breast cancer. The kinases are clinically targeted via ATP competitive …

Constitutive activation of signal transducers and activators of transcription predicts vorinostat resistance in cutaneous T-cell lymphoma

VR Fantin, A Loboda, CP Paweletz, RC Hendrickson… - Cancer research, 2008 - AACR
Vorinostat is a histone deacetylase inhibitor that induces differentiation, growth arrest, and/or
apoptosis of malignant cells both in vitro and in vivo and has shown clinical responses in∼ …

[HTML][HTML] Salvage of ribose from uridine or RNA supports glycolysis in nutrient-limited conditions

OS Skinner, J Blanco-Fernández, RP Goodman… - Nature …, 2023 - nature.com
Glucose is vital for life, serving as both a source of energy and carbon building block for
growth. When glucose is limiting, alternative nutrients must be harnessed. To identify …

[HTML][HTML] Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action

JM McFarland, BR Paolella, A Warren… - Nature …, 2020 - nature.com
Assays to study cancer cell responses to pharmacologic or genetic perturbations are
typically restricted to using simple phenotypic readouts such as proliferation rate. Information …

Noncanonical open reading frames encode functional proteins essential for cancer cell survival

JR Prensner, OM Enache, V Luria, K Krug… - Nature …, 2021 - nature.com
Although genomic analyses predict many noncanonical open reading frames (ORFs) in the
human genome, it is unclear whether they encode biologically active proteins. Here we …