Discovering the anticancer potential of non-oncology drugs by systematic viability profiling
SM Corsello, RT Nagari, RD Spangler, J Rossen… - Nature cancer, 2020 - nature.com
Anticancer uses of non-oncology drugs have occasionally been found, but such discoveries
have been serendipitous. We sought to create a public resource containing the growth …
have been serendipitous. We sought to create a public resource containing the growth …
Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity
Cultured cell lines are the workhorse of cancer research, but the extent to which they
recapitulate the heterogeneity observed among malignant cells in tumors is unclear. Here …
recapitulate the heterogeneity observed among malignant cells in tumors is unclear. Here …
Peroneal tendon subluxation: the other lateral ankle injury
JA Roth, WC Taylor, J Whalen - British journal of sports medicine, 2010 - bjsm.bmj.com
Ankle injuries are a frequent cause of patient visits to the emergency department and
orthopaedic and primary care offices. Although lateral ligament sprains are the most …
orthopaedic and primary care offices. Although lateral ligament sprains are the most …
[HTML][HTML] The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity
CK Baumgartner, H Ebrahimi-Nik, A Iracheta-Vellve… - Nature, 2023 - nature.com
Immune checkpoint blockade is effective for some patients with cancer, but most are
refractory to current immunotherapies and new approaches are needed to overcome …
refractory to current immunotherapies and new approaches are needed to overcome …
Massively parallel pooled screening reveals genomic determinants of nanoparticle delivery
To accelerate the translation of cancer nanomedicine, we used an integrated genomic
approach to improve our understanding of the cellular processes that govern nanoparticle …
approach to improve our understanding of the cellular processes that govern nanoparticle …
INK4 tumor suppressor proteins mediate resistance to CDK4/6 kinase inhibitors
Abstract Cyclin-dependent kinases 4 and 6 (CDK4/6) represent a major therapeutic
vulnerability for breast cancer. The kinases are clinically targeted via ATP competitive …
vulnerability for breast cancer. The kinases are clinically targeted via ATP competitive …
Constitutive activation of signal transducers and activators of transcription predicts vorinostat resistance in cutaneous T-cell lymphoma
VR Fantin, A Loboda, CP Paweletz, RC Hendrickson… - Cancer research, 2008 - AACR
Vorinostat is a histone deacetylase inhibitor that induces differentiation, growth arrest, and/or
apoptosis of malignant cells both in vitro and in vivo and has shown clinical responses in∼ …
apoptosis of malignant cells both in vitro and in vivo and has shown clinical responses in∼ …
[HTML][HTML] Salvage of ribose from uridine or RNA supports glycolysis in nutrient-limited conditions
Glucose is vital for life, serving as both a source of energy and carbon building block for
growth. When glucose is limiting, alternative nutrients must be harnessed. To identify …
growth. When glucose is limiting, alternative nutrients must be harnessed. To identify …
[HTML][HTML] Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action
JM McFarland, BR Paolella, A Warren… - Nature …, 2020 - nature.com
Assays to study cancer cell responses to pharmacologic or genetic perturbations are
typically restricted to using simple phenotypic readouts such as proliferation rate. Information …
typically restricted to using simple phenotypic readouts such as proliferation rate. Information …
Noncanonical open reading frames encode functional proteins essential for cancer cell survival
Although genomic analyses predict many noncanonical open reading frames (ORFs) in the
human genome, it is unclear whether they encode biologically active proteins. Here we …
human genome, it is unclear whether they encode biologically active proteins. Here we …