[PDF][PDF] Myelofibrosis: clinicopathologic features, prognosis, and management

JM O'Sullivan, CN Harrison - Clin Adv Hematol Oncol, 2018 - hematologyandoncology.net
Myelofibrosis: Clinicopathologic Features, Prognosis, and Management Page 1 Clinical
Advances in Hematology & Oncology Volume 16, Issue 2 February 2018 121 Myelofibrosis …

[HTML][HTML] Single-cell multi-omics identifies chronic inflammation as a driver of TP53-mutant leukemic evolution

A Rodriguez-Meira, R Norfo, S Wen, AL Chédeville… - Nature …, 2023 - nature.com
Understanding the genetic and nongenetic determinants of tumor protein 53 (TP53)-
mutation-driven clonal evolution and subsequent transformation is a crucial step toward the …

JAK-STAT signaling in the therapeutic landscape of myeloproliferative neoplasms

JM O'Sullivan, CN Harrison - Molecular and cellular endocrinology, 2017 - Elsevier
Myeloproliferative neoplasms (MPN) are a group of disorders defined by clonal proliferation
of mature myeloid cells with overlapping clinical features. The driver mutations of these …

Heterogeneity in myeloproliferative neoplasms: Causes and consequences

J O'Sullivan, AJ Mead - Advances in biological regulation, 2019 - Elsevier
Myeloproliferative neoplasms (MPNs) are haematopoietic stem cell-derived clonal disorders
characterised by proliferation of some or all myeloid lineages, depending on the subtype …

[PDF][PDF] Single-cell analyses reveal megakaryocyte-biased hematopoiesis in myelofibrosis and identify mutant clone-specific targets

B Psaila, G Wang, A Rodriguez-Meira, R Li… - Molecular cell, 2020 - cell.com
Myelofibrosis is a severe myeloproliferative neoplasm characterized by increased numbers
of abnormal bone marrow megakaryocytes that induce fibrosis, destroying the hematopoietic …

[HTML][HTML] Ruxolitinib versus best available therapy for polycythemia vera intolerant or resistant to hydroxycarbamide in a randomized trial

CN Harrison, J Nangalia, R Boucher… - Journal of Clinical …, 2023 - ncbi.nlm.nih.gov
Ruxolitinib Versus Best Available Therapy for Polycythemia Vera Intolerant or Resistant to
Hydroxycarbamide in a Randomized Trial - PMC Back to Top Skip to main content NIH NLM …

Single-nucleotide polymorphism alleles in the insulin receptor gene are associated with typical migraine

LC McCarthy, DA Hosford, JH Riley, MI Bird, NJ White… - Genomics, 2001 - Elsevier
We have identified a migraine locus on chromosome 19p13. 3/2 using linkage and
association analysis. We isolated 48 single-nucleotide polymorphisms within the locus, of …

Determining the recommended dose of pacritinib: results from the PAC203 dose-finding trial in advanced myelofibrosis

AT Gerds, MR Savona, BL Scott, M Talpaz… - Blood …, 2020 - ashpublications.org
PAC203 is a randomized dose-finding study of pacritinib, an oral JAK2/IRAK1 inhibitor, in
patients with advanced myelofibrosis who are intolerant of or resistant to ruxolitinib. Patients …

Single dose of BNT162b2 mRNA vaccine against severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) induces neutralising antibody and polyfunctional …

P Harrington, KJ Doores, D Radia… - British journal of …, 2021 - Wiley Online Library
Patients receiving targeted cancer treatments such as tyrosine kinase inhibitors (TKIs) have
been classified in the clinically extremely vulnerable group to develop severe acute …

[HTML][HTML] An assessment of medical students' awareness of radiation exposures associated with diagnostic imaging investigations

J O'Sullivan, OJ O'Connor, K O'Regan, B Clarke… - Insights into …, 2010 - Springer
Objectives This study assessed students' awareness of radiation exposures and determined
the impact a curriculum in clinical radiology (CICR) had on awareness. Methods Six …