Ku is of central importance to DNA repair in eukaryotes. In addition, Ku has a key role in a
number of other fundamental cellular processes such as telomere maintenance …

The integrity of the genome is frequently challenged by double-strand breaks in the DNA.
Defects in the cellular response to double-strand breaks are a major cause of cancer and …

DNA repair must take place within the context of chromatin, and it is therefore not surprising
that many aspects of both chromatin components and proteins that modify chromatin have …

Histone proteins associate with and compact eukaryotic nuclear DNA to form chromatin. The
basic unit of chromatin is the nucleosome, which is made up of 146 base pairs of DNA …

Yeast histone H2A is phosphorylated on Ser129 upon DNA damage, an event required for
efficient repair. We show that phosphorylation occurs rapidly over a large region around …

Actively transcribed regions of the genome are vulnerable to genomic instability. Recently, it
was discovered that transcription is repressed in response to neighboring DNA double …

The basic unit of chromatin in eukaryotes is the nucleosome, comprising 146 bp of DNA
wound around two copies of each of four core histones. Chromatin is further condensed by …

The mammalian INO 80 remodelling complex facilitates homologous recombination (HR),
but the mechanism by which it does this is unclear. Budding yeast INO 80 can remove H2A …

Abstract Inactivation of Polybromo 1 (PBRM1), a specific subunit of the PBAF chromatin
remodeling complex, occurs frequently in cancer, including 40% of clear cell renal cell …

BAF180, a subunit of the PBAF chromatin remodeling complex, is frequently mutated in
cancer. Although PBAF regulates transcription, it remains unclear whether this is what drives …