Chimeric antigen receptor (CAR) T cell therapy has garnered significant excitement due to
its success for hematological malignancies in clinical studies leading to the US Food and …

Oestrogen regulates several hypothalamic and pituitary hormones, which in turn control
ovarian functions. Oestrogen and its metabolites, such as catecholoestrogens, also have …

Sleep is an important determinant of collegiate athlete health, well-being and performance.
However, collegiate athlete social and physical environments are often not conducive to …

Innate immune memory is a vital mechanism of myeloid cell plasticity that occurs in
response to environmental stimuli and alters subsequent immune responses. Two types of …

Mucosal secretions of the human gastrointestinal, respiratory, and genital tracts contain
significant quantities of IgG. The mechanism by which IgG reaches luminal secretions and …

Initiation of adaptive mucosal immunity occurs in organized mucosal lymphoid tissues such
as Peyer's patches of the small intestine. Mucosal lymphoid follicles are covered by a …

The glycosphingolipid GM1 binds cholera toxin (CT) on host cells and carries it retrograde
from the plasma membrane (PM) through endosomes, the trans-Golgi (TGN), and the …

ONC201 is the founding member of a novel class of anti-cancer compounds called
imipridones that is currently in Phase II clinical trials in multiple advanced cancers. Since the …

The human MHC class I–related neonatal Fc receptor, hFcRn, mediates bidirectional
transport of IgG across mucosal barriers. Here, we find that at steady state hFcRn distributes …

ONC201/TIC10 is a first-in-class small molecule inducer of TRAIL that causes early
activation of the integrated stress response. Its promising safety profile and broad-spectrum …