There is growing evidence that structural flexibility plays a central role in the function of
protein molecules. Many of the experimental data come from nuclear magnetic resonance …

▪ Abstract During the past thirty years, deuterium labeling has been used to improve the
resolution and sensitivity of protein NMR spectra used in a wide variety of applications. Most …

Biological organisms learn from interactions with their environment throughout their lifetime.
For artificial systems to successfully act and adapt in the real world, it is desirable to similarly …

This is a detailed history of one of the most important and dramatic episodes in modern
science, recounted from the novel vantage point of the dawn of the information age and its …

Revised Manuscript Received March 10, 19949 abstract: The backbone dynamics of the C-
terminal SH2 domain of phospholipase C7I have been investigated. Two forms of the …

Revised Manuscript Received September 7, 1989 abstract: This paper describes the use of
novel two-dimensional nuclear magnetic resonance (NMR) pulse sequences toprovide …

Figure 1. Pulse sequence of the sensitivity enhanced gradient'H-15N HSQC experiment.
Narrow pulses represent a flip angle of 90 with wider pulses representing a flip angle of 180 …

Four new and complementary three-dimensional triple-resonance experiments are
described for obtaining complete backbone 1 H, 13 C, and 15 N resonance assignments of …

A unique feature of chemical catalysis mediated by enzymes is that the catalytically reactive
atoms are embedded within a folded protein. Although current understanding of enzyme …

A novel approach is described for obtaining sequential assignment of the backbone'H, I3C,
and 15N resonances of larger proteins. The approach is demonstrated for the protein …