Metabolic flexibility is the ability to respond or adapt to conditional changes in metabolic
demand. This broad concept has been propagated to explain insulin resistance and …

Exercise provides a robust physiological stimulus that evokes cross-talk among multiple
tissues that when repeated regularly (ie, training) improves physiological capacity, benefits …

The prevalence of type 2 diabetes (T2D) is rapidly increasing, and effective strategies to
manage and prevent this disease are urgently needed. Resistance training (RT) promotes …

Brown fat generates heat via the mitochondrial uncoupling protein UCP1, defending against
hypothermia and obesity. Recent data suggest that there are two distinct types of brown fat …

Obesity and type 2 diabetes have been associated with a high-fat diet (HFD) and reduced
mitochondrial mass and function. We hypothesized a HFD may affect expression of genes …

GDF15 is an established biomarker of cellular stress. The fact that it signals via a specific
hindbrain receptor, GFRAL, and that mice lacking GDF15 manifest diet-induced obesity …

There is evidence from human twin and family studies as well as mouse and rat selection
experiments that there are considerable interindividual differences in the response of …

Abstract Perilipin 5 (PLIN5/OXPAT) is a lipid droplet (LD) coat protein mainly present in
tissues with a high fat-oxidative capacity, suggesting a role for PLIN5 in facilitating fatty acid …

Results: Macrophage and T-cell markers were upregulated in SM of obese compared with
lean humans. SM of obese mice had higher expression of inflammatory cytokines, with …

Type 2 diabetes is characterized by excessive lipid storage in skeletal muscle. Excessive
intramyocellular lipid (IMCL) storage exceeds intracellular needs and induces lipotoxic …