Immune reconstitution disease (IRD) in HIV-infected patients is an adverse consequence of
the restoration of pathogen-specific immune responses during the initial months of highly …

The AIDS epidemic has been a global public health issue for more than 40 years and has
resulted in~ 40 million deaths. AIDS is caused by the retrovirus, HIV-1, which is transmitted …

Executive summary Inspired by unprecedented improvements in human health and
development in recent decades, our world has embarked on a quest that only a generation …

Background Antiretroviral chemoprophylaxis before exposure is a promising approach for
the prevention of human immunodeficiency virus (HIV) acquisition. Methods We randomly …

Preliminary Data on Vaccine Protection against Omicron Using a test-negative study design
focused on the period of dominance of the B. 1.1. 529 (omicron) variant in South Africa …

Abstract The SARS-CoV-2 Omicron variant (B. 1.1. 529) has multiple spike protein
mutations, that contribute to viral escape from antibody neutralization,,–and reduce vaccine …

Background The effect of HIV pre-exposure prophylaxis (PrEP) depends on uptake,
adherence, and sexual practices. We aimed to assess these factors in a cohort of HIV …

Drug concentrations associated with protection from HIV-1 acquisition have not been
determined. We evaluated drug concentrations among men who have sex with men in a …

Background Antiretroviral medications that are used as prophylaxis can prevent acquisition
of human immunodeficiency virus type 1 (HIV-1) infection. However, in clinical trials among …

The development of a rapid and efficient system to identify human immunodeficiency virus
type 1 (HIV-1)-infected individuals with broad and potent HIV-1-specific neutralizing …