Objective To investigate the efficacy, acceptability, and safety of muscle relaxants for low
back pain. Design Systematic review and meta-analysis of randomised controlled trials …

Objective To evaluate the comparative effectiveness and safety of analgesic medicines for
acute non-specific low back pain. Design Systematic review and network meta-analysis …

Background Exercise is recommended for the management of chronic low back pain
(CLBP). Trialists have proposed numerous mechanisms to explain why exercise improves …

Importance The effects of altered neural processing, defined as altering neural networks
responsible for perceptions of pain and function, on chronic pain remains unclear. Objective …

Background Antidepressant medicines are used to manage symptoms of low back pain. The
efficacy, acceptability, and safety of antidepressant medicines for low back pain (LBP) are …

Importance Observational (nonexperimental) studies that aim to emulate a randomized trial
(ie, the target trial) are increasingly informing medical and policy decision-making, but it is …

The potential benefits of combining pain education (PE) with clinical hypnosis (CH) has not
yet been investigated in individuals with chronic pain. A total of 100 patients with chronic …

A new wave of treatments has emerged to target nervous system alterations and
maladaptive conceptualizations about pain for chronic low back pain. The acceptability of …

Background Pharmacological interventions are the most used treatment for low back pain
(LBP). Use of evidence from systematic reviews of the effects of pharmacological …

Mediation analysis is a common statistical method used to investigate mechanisms of health
exposure and interventions. The reporting quality of mediation studies used in randomised …