In 1907, Alois Alzheimer described the case of a 51 year old woman who presented with a
relatively rapidly deteriorating memory along with psychiatric disturbances. She died four …

Genetic and lifestyle-related risk factors for Alzheimer disease (AD) are associated with an
increase in oxidative stress, suggesting that oxidative stress is involved at an early stage of …

Although iron is essential in maintaining the function of the central nervous system, it is a
potent source of reactive oxygen species. Excessive iron accumulation occurs in many …

The 2017 Concussion in Sport Group (CISG) consensus statement is designed to build on
the principles outlined in the previous statements 1–4 and to develop further conceptual …

Biochemical studies show that phosphorylated τ, like that found in paired helical filaments
(PHFs), does not promote microtubule assembly leading to the view that PHF formation …

8-hydroxy-2′-deoxyguanosine (8-OHdG) or 8-hydroxyguanosine (8-OHG), a product of
oxidized DNA or RNA, is a good marker of oxidative cellular damage. In this study, we …

Central to the oxidative stress hypothesis of Parkinson's disease (PD) pathogenesis is the
ability of iron to generate hydroxyl radicals via the Fenton reaction, and the consistent …

Advanced glycation end products are a diverse class of posttranslational modifications,
stemming from reactive aldehyde reactions, that have been implicated in the pathogenesis …

The management of Alzheimer's disease (AD) has been a long-standing challenge and area
of interest. Advances in knowledge of the pathogenesis of disease and an increase in …

Oxidative stress is a well‐studied early response in chronic neurodegenerative diseases,
including Alzheimer's disease, where neuronal loss can exceed 90% in the vulnerable …