[HTML][HTML] Alzheimer disease
RJ Castellani, RK Rolston, MA Smith - Disease-a-month: DM, 2010 - ncbi.nlm.nih.gov
In 1907, Alois Alzheimer described the case of a 51 year old woman who presented with a
relatively rapidly deteriorating memory along with psychiatric disturbances. She died four …
relatively rapidly deteriorating memory along with psychiatric disturbances. She died four …
Involvement of oxidative stress in Alzheimer disease
A Nunomura, RJ Castellani, X Zhu… - … of neuropathology & …, 2006 - academic.oup.com
Genetic and lifestyle-related risk factors for Alzheimer disease (AD) are associated with an
increase in oxidative stress, suggesting that oxidative stress is involved at an early stage of …
increase in oxidative stress, suggesting that oxidative stress is involved at an early stage of …
Iron: the Redox-active center of oxidative stress in Alzheimer disease
Although iron is essential in maintaining the function of the central nervous system, it is a
potent source of reactive oxygen species. Excessive iron accumulation occurs in many …
potent source of reactive oxygen species. Excessive iron accumulation occurs in many …
Consensus statement on concussion in sport—the 5th international conference on concussion in sport held in Berlin, October 2016
P McCrory, W Meeuwisse, J Dvorak, M Aubry… - British journal of sports …, 2017 - bjsm.bmj.com
The 2017 Concussion in Sport Group (CISG) consensus statement is designed to build on
the principles outlined in the previous statements 1–4 and to develop further conceptual …
the principles outlined in the previous statements 1–4 and to develop further conceptual …
Microtubule reduction in Alzheimer's disease and aging is independent of τ filament formation
AD Cash, G Aliev, SL Siedlak, A Nunomura… - The American journal of …, 2003 - Elsevier
Biochemical studies show that phosphorylated τ, like that found in paired helical filaments
(PHFs), does not promote microtubule assembly leading to the view that PHF formation …
(PHFs), does not promote microtubule assembly leading to the view that PHF formation …
Systemic increase of oxidative nucleic acid damage in Parkinson's disease and multiple system atrophy
A Kikuchi, A Takeda, H Onodera, T Kimpara… - Neurobiology of …, 2002 - Elsevier
8-hydroxy-2′-deoxyguanosine (8-OHdG) or 8-hydroxyguanosine (8-OHG), a product of
oxidized DNA or RNA, is a good marker of oxidative cellular damage. In this study, we …
oxidized DNA or RNA, is a good marker of oxidative cellular damage. In this study, we …
Sequestration of iron by Lewy bodies in Parkinson's disease
RJ Castellani, SL Siedlak, G Perry, MA Smith - Acta neuropathologica, 2000 - Springer
Central to the oxidative stress hypothesis of Parkinson's disease (PD) pathogenesis is the
ability of iron to generate hydroxyl radicals via the Fenton reaction, and the consistent …
ability of iron to generate hydroxyl radicals via the Fenton reaction, and the consistent …
Active glycation in neurofibrillary pathology of Alzheimer disease: Nε-(carboxymethyl) lysine and hexitol-lysine
RJ Castellani, PLR Harris, LM Sayre, J Fujii… - Free Radical Biology …, 2001 - Elsevier
Advanced glycation end products are a diverse class of posttranslational modifications,
stemming from reactive aldehyde reactions, that have been implicated in the pathogenesis …
stemming from reactive aldehyde reactions, that have been implicated in the pathogenesis …
Current approaches in the treatment of Alzheimer's disease
The management of Alzheimer's disease (AD) has been a long-standing challenge and area
of interest. Advances in knowledge of the pathogenesis of disease and an increase in …
of interest. Advances in knowledge of the pathogenesis of disease and an increase in …
Oxidative stress and neurodegeneration
PI Moreira, MA Smith, X Zhu… - Annals of the New …, 2005 - Wiley Online Library
Oxidative stress is a well‐studied early response in chronic neurodegenerative diseases,
including Alzheimer's disease, where neuronal loss can exceed 90% in the vulnerable …
including Alzheimer's disease, where neuronal loss can exceed 90% in the vulnerable …