Some phthalates are developmental and reproductive toxicants in animals. Exposure to
phthalates is considered to be potentially harmful to human health as well. Based on a …

Background Endotoxins are commonly found at workplaces where large amounts of
bioaerosols are generated. In Germany, especially since the Ordinance on Safety and …

Inherited genetic traits co-determine the susceptibility of an individual to a toxic chemical.
Special emphasis has been put on individual responses to environmental and industrial …

Stratification of women according to their risk of breast cancer based on polygenic risk
scores (PRSs) could improve screening and prevention strategies. Our aim was to develop …

Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as
BRCA1, and many common, mostly non-coding variants. However, much of the genetic …

Breast cancer is the most common cancer among women. Common variants at 27 loci have
been identified as associated with susceptibility to breast cancer, and these account for∼ …

Background Previous studies have suggested that breast cancer risk factors are associated
with estrogen receptor (ER) and progesterone receptor (PR) expression status of the tumors …

The timing of puberty is a highly polygenic childhood trait that is epidemiologically
associated with various adult diseases. Using 1000 Genomes Project–imputed genotype …

Lung cancer is mainly caused by smoking, but the quantitative relations between smoking
and histologic subtypes of lung cancer remain inconclusive. By using one of the largest lung …

Background: Data for multiple common susceptibility alleles for breast cancer may be
combined to identify women at different levels of breast cancer risk. Such stratification could …