The flagellum in bacterial pathogens: for motility and a whole lot more

B Chaban, HV Hughes, M Beeby - Seminars in cell & developmental …, 2015 - Elsevier
The bacterial flagellum is an amazingly complex molecular machine with a diversity of roles
in pathogenesis including reaching the optimal host site, colonization or invasion …

Risk of comorbidities following physician‐diagnosed knee or hip osteoarthritis: a register‐based cohort study

A Dell'Isola, K Pihl, A Turkiewicz… - Arthritis care & …, 2022 - Wiley Online Library
Objective To estimate the risk of developing comorbidities in patients after physician‐
diagnosed knee or hip osteoarthritis (OA). Methods This was a cohort study using Swedish …

[HTML][HTML] The impact of first and second wave of COVID-19 on knee and hip surgeries in Sweden

A Dell'Isola, A Kiadaliri, A Turkiewicz, V Hughes… - Journal of Experimental …, 2021 - Springer
Purpose To investigate the impact of COVID-19 in Sweden on rates of knee and hip
surgeries. Methods We used healthcare data for the population of the southernmost region …

In Situ Probing of Newly Synthesized Peptidoglycan in Live Bacteria with Fluorescent D‐Amino Acids

E Kuru, HV Hughes, PJ Brown, E Hall… - Angewandte …, 2012 - Wiley Online Library
Bacterial growth is controlled by the peptidoglycan (PG) cell wall, a rigid and essential
structure composed of glycan strands cross-linked by d-amino acid (DAA)-containing short …

Physiological role of stalk lengthening in Caulobacter crescentus

EA Klein, S Schlimpert, V Hughes, YV Brun… - … & integrative biology, 2013 - Taylor & Francis
The Gram-negative bacterium Caulobacter crescentus forms a thin polar stalk, which
mediates its attachment to solid surfaces. Whereas stalks remain short (1 µm) in nutrient-rich …

[HTML][HTML] Three-dimensional microstructure of human meniscus posterior horn in health and osteoarthritis

I Kestilä, E Folkesson, MA Finnilä, A Turkiewicz… - Osteoarthritis and …, 2019 - Elsevier
Objective To develop and perform ex vivo 3D imaging of meniscus posterior horn
microstructure using micro-computed tomography (μCT), and to compare specimens from …

Peptidoglycan transformations during Bacillus subtilis sporulation

EI Tocheva, J López‐Garrido, HV Hughes… - Molecular …, 2013 - Wiley Online Library
While vegetative B acillus subtilis cells and mature spores are both surrounded by a thick
layer of peptidoglycan (PG, a polymer of glycan strands cross‐linked by peptide bridges), it …

Mineral crystal thickness in calcified cartilage and subchondral bone in healthy and osteoarthritic human knees

MAJ Finnilä, S Das Gupta, MJ Turunen… - Journal of Bone and …, 2020 - academic.oup.com
Osteoarthritis (OA) is the most common joint disease, where articular cartilage degradation
is often accompanied with sclerosis of the subchondral bone. However, the association …

Protein localization and dynamics within a bacterial organelle

HV Hughes, E Huitema, S Pritchard… - Proceedings of the …, 2010 - National Acad Sciences
Protein localization mechanisms dictate the functional and structural specialization of cells.
Of the four polar surface organelles featured by the dimorphic bacterium Caulobacter …

Co‐ordinate synthesis and protein localization in a bacterial organelle by the action of a penicillin‐binding‐protein

HV Hughes, JP Lisher, GG Hardy… - Molecular …, 2013 - Wiley Online Library
Organelles with specialized form and function occur in diverse bacteria. Within the A
lphaproteobacteria, several species extrude thin cellular appendages known as stalks …