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Outbreak in meldonium positive laboratory tests: are we missing something?
  1. Alice Panchaud1,2,
  2. Chantal Csajka1,2
  1. 1School of Pharmaceutical Sciences, University of Geneva and University of Lausanne, Geneva, Switzerland
  2. 2Division of Clinical Pharmacology, Service of Biomedicine, Department of Laboratory, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
  1. Correspondence to Dr Alice Panchaud, School of Pharmaceutical Sciences, University of Geneva and University of Lausanne, Geneva, Switzerland; alice.panchaud{at}chuv.ch

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As clinicians facing the challenges associated with the interpretation of drug concentrations or clinical laboratory measures in our daily practice, the outbreak of adverse analytical findings reported on meldonium makes us wonder if the information on meldonium available to date is sufficient to adequately interpret such findings. An adequate interpretation of a drug concentration requires knowledge of its pharmacokinetic characteristics and profile over time, and this has not been studied fully for meldonium.

Available studies suggest that meldonium is eliminated mainly by the kidneys. Single dose administration showed …

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